UNLABELLED Absorbed-dose calculations provide a scientific basis for evaluating the biologic effects associated with administered radiopharmaceuticals. In cancer therapy, radiation dosimetry supports treatment planning, dose-response analyses, predictions of therapy effectiveness, and completeness of patient medical records. In this study, we evaluated the organ radiation absorbed doses from in...

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...

background: recent pre-clinical and clinical studies indicate that irradiation in the dose range of 15 to 30 gy can reduce rate of restenosis in patients who have undergone an angioplasty. the use of filled balloon with radioactive solution was proposed as one of the possible intravascular irradiation techniques. materials and methods: the monte carlo n-particle transport code (mcnp4b) was used...

The purpose of the present work is to calculate specific absorbed fractions using variance reduction techniques and assess the effectiveness of these techniques in improving the efficiency (i.e. reducing the statistical uncertainties) of simulation results in cases where the distance between the source and the target organs is large and/or the target organ is small. The variance reduction techn...

In nuclear medicine and particularly in internal radiotherapy, one of the major challenges is to determine the dose for each patient. Current internal dosimetric estimations are based on the Medical Internal Radiation Dose (MIRD) formalism and use standard mathematical models. These standard models are often far from a given patient morphology and do not allow to perform patient-specific dosime...

Aim: Calculating the absorbed dose is important for the determination of risk and therapeutic benefit of internal radiation therapy. Optimal dose estimations require time-consuming and sophisticated methods, which are difficult due to practical reasons. To make dosimetry available for each of the patients, we developed a specific dosimetry procedure used in daily clinical routine. Materials and...