The solution structures of calicheamicin gamma 1I, its cycloaromatized analog (calicheamicin epsilon), and its aryl tetrasaccharide complexed to a common DNA hairpin duplex have been determined by NMR and distance-refined molecular dynamics computations. Sequence specificity is associated with carbohydrate-DNA recognition that places the aryl tetrasaccharide component of all three ligands in si...

Graphene annulus possesses special wrinkling phenomenon with wide range of potential applications. Using molecular dynamics simulation, this study concerns the effect of boundary on the mechanical properties of circular and elliptical graphene annuli under circular shearing at inner edge. Both the wrinkle characteristic and torque capacity of annular graphene can be effectively tuned by outer b...

Background To retrospectively analyse strategies for adjusting refractive surgery plans with reference to the preoperative manifest refraction. Methods We constructed seven nomograms based on the refractive outcomes (sphere, cylinder, axis [SCA]) of 150 consecutive eyes treated with laser in situ keratomileusis for myopic astigmatism. We limited the initial data to the SCA of the manifest ref...

Fructose-1,6-bisphosphatase (FBPase) is a key regulator of gluconeogenesis and a potential drug target for type 2 diabetes. FBPase is a homotetramer of 222 symmetry with a major and a minor dimer interface. The dimers connected via the minor interface can rotate with respect to each other, leading to the inactive T-state and active R-state conformations of FBPase. Here, the first crystal struct...

We just started an observational program to obtain 2D kinematics of nuclear bars, to be compared to N body simulations of single and double-barred galaxies. We have started a program to study the kinematics of double-barred galaxies using the Integral Field Spectrograph OASIS (CFHT). Stellar bidimensional velocity fields obtained with OASIS are compared with N body + SPH simulations, to constra...

Physical forces arising in the cellular microenvironment have been hypothesized to play a major role in governing cell function. Moreover, it is thought that gene regulation may be sensitive to nuclear deformations taking place in response to extracellular forces over short and long timescales. Although nuclear responses to mechanical stimuli over long timescales are relatively well studied, th...

Abstract In this study, a new expansion of planetary disturbing function is developed for describing the resonant dynamics minor bodies with arbitrary inclinations and semimajor axis ratios. practice, expanded around circular orbits in first step then, second step, resulting mutual interaction between reference point. As usual, presented Fourier series form, where force amplitudes are dependent...

ABSTRACT We study the distribution and dynamics of circumgalactic intergalactic medium using a dense galaxy survey covering field around Q0107 system, unique z ? 1 projected quasar triplet. With full Ly ? coverage along all three lines-of-sight from = 0.18 to 0.73, more than 1200 spectra, two MUSE fields, we examine structure gas galaxies on 100–1000 kpc scales. search for H i absorption system...

A new curve is produced and graphically studied. The name of my daughter, Nada, has been given to this curve; in other words, Nada used describe whenever it paper. “Nada’s curve” a form closed that constructed when the circle’s diameter ellipse’s minor axis share same length, they are tangent by point from drawn line passing through circumstances circle ellipse. Then, these two intersection poi...