نتایج جستجو برای: minigenome

تعداد نتایج: 153  

Journal: :Journal of virology 2012
Stephen D Carter Rebecca Surtees Cheryl T Walter Antonio Ariza Éric Bergeron Stuart T Nichol Julian A Hiscox Thomas A Edwards John N Barr

Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging tick-borne virus of the Bunyaviridae family that is responsible for a fatal human disease for which preventative or therapeutic measures do not exist. We solved the crystal structure of the CCHFV strain Baghdad-12 nucleocapsid protein (N), a potential therapeutic target, at a resolution of 2.1 Å. N comprises a large globular domain co...

Journal: :The Journal of biological chemistry 2004
Abdur Rahaman Naryanaswamy Srinivasan Narayanaswamy Shamala Melkote Subbarao Shaila

Phosphoprotein (P) of negative sense RNA viruses functions as a transcriptional transactivator of the viral polymerase (L). We report here the characterization of oligomeric P protein of rinderpest virus (RPV) and provide a structural basis for its multimerization. By size exclusion chromatography and dynamic light scattering analyses we show that bacterially expressed P protein exists as an ol...

Journal: :Journal of virology 2007
Derek Ostertag Traci M Hoblitzell-Ostertag Jacques Perrault

In a companion paper (D. Ostertag, T. M. Hoblitzell-Ostertag, and J. Perrault, J. Virol. 81:492-502, 2007), we provided indirect evidence that cell-type-specific growth restriction of the vesicular stomatitis virus (VSV) polR mutants may be due to enhanced production of double-stranded RNA (dsRNA). We show here that polR growth in mouse L-929 cells was rescued by vaccinia virus coinfection and ...

Journal: :Journal of virology 2014
Adrian Pickar Pei Xu Andrew Elson Zhuo Li James Zengel Biao He

UNLABELLED Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing mumps cases. However, recently large outbreaks have occurred in vaccinated populations. There is no ant...

2013
Masfique Mehedi Thomas Hoenen Shelly Robertson Stacy Ricklefs Michael A. Dolan Travis Taylor Darryl Falzarano Hideki Ebihara Stephen F. Porcella Heinz Feldmann

Ebolavirus (EBOV), the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adenosine residues are incorporated into the EBOV mRNAs at an editing site encoding...

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