A 53-year-old white woman with epidermolysis bullosa (EB) pruriginosa presented to the dermatology clinic seeking therapy for localized severe and intractable pruritus. At the age of 4 years the patient developed an extremely pruritic bullous eruption characterized by fragile blisters, erosions, and excoriations affecting sites subject to friction and pressure, particularly the ankles and knees...

Bazex-Dupre-Christol syndrome (BDCS) is an X linked dominant disorder of the hair follicle characterised by follicular atrophoderma, multiple basal cell carcinomas, hypotrichosis, milia, and localised hypohidrosis. Follicular atrophoderma (FA) are follicular funnel shaped depressions, "ice pick marks", seen most commonly on the dorsum of the hands. We describe the first known Scottish family wi...

Melanoma is characterised by a variety of clinical and histopathological presentations. Dermoscopy is a fast, non-invasive technique that increases diagnostic accuracy for both melanocytic and non-melanocytic skin tumours. One example of a potential pitfall in melanoma diagnosis using dermoscopy is represented by seborrheic keratosis (SK) that looks like melanomas, which may show overlapping fe...

Recessive dystrophic epidermolysis bullosa of Hallopeau-Siemens (RDEB-HS) is a rare genetic disorder characterized by trauma-induced blisters, milia, acral pseudosyndactyly, and scarring. RDEB-HS patients present with a distinct pattern of oral involvement consisting of microstomia, ankyloglossia, vestibule obliteration and dental caries. In this review, we describe the orodental manifestations...

Roberto S, Marongiu E, Pinna M, Angius L, Olla S, Bassareo P, Tocco F, Concu A, Milia R, Crisafulli A. Altered hemodynamics during muscle metaboreflex in young type 1 diabetes patients. J Appl Physiol 113: 1323–1331, 2012. First published June 14, 2012; doi:10.1152/japplphysiol.00280.2012.—A reduction in catecholamine levels during exercise has been described in young subjects with type 1 diabe...

History A 12-year-old boy presented with a history of blistering due to trauma on both shins since birth. They healed with scarring and milia formation. The lesions mainly affected the shins and some occasionally appeared on the waist. They were mildly pruritic and were worse in the summer as well as being precipitated by trauma. There was also toenail dystrophy but his hair and teeth were norm...

OBJECTIVE To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality. METHODS Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists. RESULTS 2938 neonates aged up to thre...

Discussion |Threemuscles, thecircularorbicularis oris, depressor labii inferioris, andmentalis align the labiomental fold or cross it as they pass to their insertion.2 The fibers of the 3 muscles are attached to the skin by thick bands of fibroelastic fibers. Thementalismuscles originate from themandible and serve as paired elevators of the central lower lip.3 They usually overlap and insert in...

To editor, Gout is a common rheumatological disease caused by a disturbance in uric acid metabolism. Tophi develop during most advanced clinical stage of gout, and usually present as firm pink nodules or fusiform swelling, mainly at periarticular sites. However, unusual skin manifestations caused by intradermal and subcutaneous deposition of tophaceous material at locations other than periartic...

OBJECTIVE To provide incidence data based on ethnicity, prematurity, and body site for vascular, pigmented, and other common congenital cutaneous findings; to compare these results with previously published prospective studies; and to define updated nomenclature, classification, clinical course, and prognostic factors for the pediatric practitioner to promote a better understanding of benign ve...