The psychometric properties of the Self-Report Depression Questionnaire (SRDQ) were evaluated, extending a previous assessment of this instrument. Data from two independent studies (Esbensen, 2004; Seltzer & Krauss, 1989) were pooled to generate a sample of 192 individuals with primarily mild or moderate mental retardation. Reliability estimates of this questionnaire were good to excellent and ...

The purpose was to examine the reliability of physical fitness items from the Eurofit Test Battery for adolescent males with mild mental retardation (MMR; n = 63, mean IQ = 63.0 k11.5, mean age = 15.5 k 1.2) and those without (n = 22, mean age = 15.6 ? 0.6). Males with MMR scored significantly lower (p I .005) than those without on all items except sum of skinfolds, height, and weight. Intracla...

A 53-year-old Japanese woman presented with mild mental retardation, short stature, hypertelorism, saddle nose, vertebral fusion, and hydrocephalus, implying an underlying bone growth impairment mainly of the head and neck. A point mutation in fibroblast growth factor receptor 2 (FGFR2) was identified that had previously been seen only in sporadic cases of Crouzon syndrome. This patient did not...

A postal questionnaire was used to study 49 individuals with Cornelia de Lange syndrome (including both the classical and the mild forms) to ascertain behavioural phenotype. Ages ranged from early childhood to adulthood (mean age, 10.2 years; SD, 7.8) and the degree of mental retardation from borderline (10%), through mild (8%), moderate (18%), and severe (20%) to profound (43%). A wide variety...

The disease burden from exposure to lead resulting in mild mental retardation (due to IQ point decreases) and cardiovascular outcomes (due to increases in blood pressure) was estimated at a global level. Blood lead levels were compiled from the literature for 14 geographical regions defined by the World Health Organization according to location and adult and child mortality rates. Adjustments w...

This study evaluated the relationship between leg strength and endurance run performance, independent of aerobic capacity (\;TOzp,,), body size, and gender, in children and adolescents with mild or moderate mental retardation. Twenty-six individuals (15 boys and 1 I girls) volunteered and underwent tests of YOzp,,, isokinetic leg strength, and endurance run performance (600-yard rudwalk and 20-...

One morphological variant of chromosome 1 in man differs from the more usual form of this chromosome in being longer and more submetacentric. This is due to increased length of the long arm and because there is apposition of chromatids in the paracentromeric region of the long arm (q). This variant, or similar appearing variants ofchromosome 1, have been found in 1 per 100 to 1 per 1000 newborn...

A case of congenital bilateral perisylvian syndrome (CBPS) associated with bilateral perisylvian schizencephaly in a 24-year-old woman is reported. She presented the classical clinical triad of CBPS, which included congenital facio-masticatory diplegia, epilepsy and only mild mental retardation, despite the presence of bilateral, open-lip clefts in the perisylvian region. We hypothesize that th...

The high-functioning Autism Spectrum Screening Questionnaire (ASSQ) is a 27-item checklist for completion by lay informants when assessing symptoms characteristic of Asperger syndrome and other high-functioning autism spectrum disorders in children and adolescents with normal intelligence or mild mental retardation. Data for parent and teacher ratings in a clinical sample are presented along wi...

A.L., a 42-yr-old man has been in treatment at our out- patient clinic since 1992 suffering from psychotic manifestations following a second severe closed-head injury. The patient had his first contact with a psychiatrist 3 yr after his first severe head injury in 1962 (when 10 yr old). During his first hospitalization (in 1994) he presented with signs of affective flattening and behavioural pr...