BACKGROUND The construct "meaning-in-life" (MiL) has recently raised the interest of clinicians working in psycho-oncology and end-of-life care and has become a topic of scientific investigation. Difficulties regarding the measurement of MiL are related to the various theoretical and conceptual approaches and its inter-individual variability. Therefore the "Schedule for Meaning in Life Evaluati...

Bone mass is the most important determinant of the mechanical strength of bones, and spatial structure is the second. In general, the spatial structure and mechanical properties of bones such as the breaking strength are direction dependent. The mean intercept length (MIL) and line frequency deviation (LFD) are two methods for quantifying directional aspects of the spatial structure of bone. Yo...

MOTIVATION High-content screening (HCS) technologies have enabled large scale imaging experiments for studying cell biology and for drug screening. These systems produce hundreds of thousands of microscopy images per day and their utility depends on automated image analysis. Recently, deep learning approaches that learn feature representations directly from pixel intensity values have dominated...

The new aluminium based metal-organic framework [Al(OH)(O2C-C4H8-CO2)]·H2O denoted as Al-MIL-53-ADP-lp (lp stands for large pore) was synthesised under solvothermal conditions. This solid is an analogue of the archetypical aluminium terephthalate Al-MIL-53 based on the aliphatic single-chain linker molecule adipic acid (H2ADP, hexanedioic acid). In contrast to its aromatic counterparts, Al-MIL-...

PURPOSE To determine the role of the murine interleukin-8 receptor homologue (mIL-8Rh, neutrophil chemokine CXC receptor 2) in leukocyte migration using intravital microscopy in a standardized model of eye inflammation, endotoxin-induced uveitis (EIU). METHODS Two hundred fifty nanograms of E. coli endotoxin was injected into the vitreous of knockout mIL-8Rh(-/-) (n = 7) mice or heterozygous ...

The Multiple Instance Learning (MIL) framework has been extensively used to solve weakly labeled visual classification problems, where each image or video is treated as a bag of instances. Instance Space based MIL algorithms construct a classifier by modifying standard classifiers by defining the probability that a bag is of the target class as the maximum over the probabilities that its instan...

________________________________________________________________________________ Abstract A total of 210 day-old male Cobb broiler chickens were randomly assigned to six treatments in a 3 × 2 factorial design. The treatments consisted of three levels of maize: 250 g/kg (LM), 500 g/kg (MM) and 750 g/kg diet (HM) and two levels of enzymes: plus enzyme and no enzyme. Each treatment was replicated ...

IL-18 is an important cytokine in autoimmune and inflammatory diseases through the induction of IFN-gamma, TNF-alpha, and IL-1. We report herein that collagen-induced arthritis (CIA) in mice is inhibited by treatment with murine IL-18 binding protein (mIL-18BP). CIA was induced in DBA/1J mice by the injection of bovine type II collagen (CII) in IFA with added Mycobacterium tuberculosis on days ...

Bone mass is the most important determinant of the mechanical strength of bones and spatial structure is the second. In general the spatial structure and mechanical properties of bones such as the breaking strength are directional dependent. The Mean Intercept Length (MIL) and Line Frequency Deviation (LFD) are two methods for quantifying directional aspects of the spatial structure of bone. Th...

Recombinant mouse interleukin 22 (mIL-22) and its variants encoding four muteins (Y51A, N54A, R55A and E117A) were expressed in Escherichia coli, refolded and purified to homogeneity as monomeric proteins by one-step ion-exchange chromatography. The binding of IL-22 and its four muteins to immobilized mIL-22 receptor α1 extracellular domain (mIL-22 Rα1-ECD) exhibited similar affinity, indicatin...