Objective The aim of the present research was to compare the effectiveness and tolerability of melatonin and amitriptyline in pediatric migraine prevention. Materials & Methods In a parallel single-blinded randomized clinical trial, 5-15 yr old children with diagnosis of migraine that preventive therapy was indicated in whom and were referred to Pediatric Neurology Clinic of Shahid Sadoughi M...

BACKGROUND Autologous adipose-derived stromal vascular fraction (SVF), which is rich in mesenchymal stromal cells, has been reported to be effective for the treatment of trigeminal neuropathic pain and chronic migraine and tension-type headaches. It is possible that stem cell activity targets neurogenic inflammation, which is a well-documented aspect of migraine pathogenesis. METHODS Adult pa...

BACKGROUND Recent studies have shown a positive correlation between Helicobacter pylori (H. pylori)infection and migraine headache. OBJECTIVE To study the impact of H. pylori eradication on migraine headache. STUDY DESIGN Double blind, randomized, controlled clinical trial. SETTING Sixty-four patients diagnosed with migraine-type headache were included in the study. The patients were rand...

BACKGROUND Migraine is a common disabling disease but its economic burden has not been adequately quantified. OBJECTIVE To estimate the burden of migraine in the United States with respect to disability and economic costs. METHODS The following data sources were used: published data, the Baltimore County Migraine Study, MEDSTAT's MarketScan medical claims data set, and statistics from the C...

Objective: Determine the frequency of migraine, its triggering factors and assessment impact on daily life among medical students ofa private college in Lahore, Pakistan. Settings: First to final year MBBS Fatima Memorial College Medicine, Lahore Period: February April, 2019. Material & Methods: In a total 708 students, 118 were identified, as having experienced headache for past one year. ...

Background & Objective:  Migraine is an occasional headache that represents neurological and gastrointestinal symptoms, as well changes in the autonomic nervous system. Biofeedback a non-pharmacological technique used to treat migraine headaches proven reduce improve performance. The present study aimed compare efficacy of biofeedback pharmacological treatments find best treatment strategy for ...

Abstract Background Results of previous trials about PFO closure as a treatment for migraine are still doubtful and inconclusive. We sought to evaluate the long–term (>10 years) effectiveness by means patent foramen ovale (PFO) closure. Methods From 2006 2010, 86 patients (68 female, mean age 40.0 ±3.7 with disabling, medication–refractory were enrolled in prospective study over 48–month...

BACKGROUND Recent studies evaluated short-term efficacy and safety of peripheral nerve stimulation (PNS) of the occipital nerves for managing chronic migraine. We present 52-week safety and efficacy results from an open-label extension of a randomized, sham-controlled trial. METHODS In this institutional review board-approved, randomized, multicenter, double-blinded study, patients were impla...

BACKGROUND The Disability in Strategies for Care (DISC) study was the first large randomised controlled trial to compare alternative treatment strategies in the acute treatment of migraine. With 835 patients in its intention-to-treat efficacy analysis, DISC compared a stratified care strategy, where initial therapy was based on clinical need as determined by the Migraine Disability Assessment S...