A single ‘odd’ interaction can cause two user interaction sessions to diverge in similarity, and stand in the way of generalization. The sensitivity of session-based recommenders to session similarity motivates us to explicitly identify and remove such ‘similarity blockers’. Specifically, we leverage huge amounts of data, which allow us to identify blockers in the form of non-co-occurring items...

With numerous safe and effective antihypertensive drugs now available, the clinician should no longer choose only diuretic agents or beta-adrenergic receptor blockers (beta-blockers) as initial therapy. Five classes of agents, including angiotensin converting enzyme inhibitors, beta-blockers, calcium entry blockers, peripheral alpha 1-adrenergic receptor blockers, and thiazide diuretic agents, ...

This research explored experiences of transgender children and their families approaching into adolescence, understanding relating to puberty blocking medication. Data were drawn from 30 parents trans adolescents who at time interview, an average age 11 years old. Parental interviewees 90% white, 93% female, 100% cis, 60% heterosexual. Additional data 10 adolescents, 12 Interviews held remotely...

The treatment of migraine depends on the frequency, severity and concomitant diseases. There are several specific drugs developed for migraine prevention in addition to the additive antimigraine effects of some other non-specific drugs. The aim of this literature-based review is to summarize the possible antimigraine properties of different antihypertensive agents (beta-blockers, calcium channe...

The knowledge of the impact of beta-blockers on Coronary Flow Reserve (CFR) is based on experimental and clinical studies which used invasive methods (mainly Doppler Flow Wire, DFW) and non-invasive tools including scintigraphic (mainly Positron Emission Tomography, PET), magnetic resonance and Doppler ultrasound imaging. Beta-blockers have a large therapeutic indication in the treatment of cor...

Introduction: Gastric acidity plays an important role in the protection of infants against various pathogens from environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that frequently prescribed preterm neonates to prevent stress ulcers. impact H2-blockers on development necrotizing enterocolitis (NEC) is still controversial, particularly developing world. Materials...