Boron Neutron Capture Therapy (BNCT) is a rather innovative cancer radiotherapy; at present it is object of increasing interest especially for treatment of those tumors where conventional therapy gives not satisfactory results (Glioblastoma and Malignant Melanoma). The therapy takes advantage of both chemical and physical aspects B: the possibility of selectively accumulating in tumor tissue th...

Prior work has provided incremental phases to a microdosimetry modeling program to describe the dose response behavior of the radio-protective adaptive response effect. We have here consolidated these prior works (Leonard 2000, 2005, 2007a, 2007b, 2007c) to provide a composite, comprehensive Microdose Model that is also herein modified to include the bystander effect. The nomenclature for the m...

An algorithm for the derivation of LET-distributions from pulse-height spectra obtained with proportional counters is described. The method is based on Fourier transformation; it is applicable to spherical as well as non-spherical proportional counters. The relation between the energy mean, E,, of LET and the energy mean, g , , of the lineal energy density is given. 1. Introduction Tissue equiv...

The murine B-cell lymphoma 38C13 model was used to study the radiobiological effect of 13ll-monoclonal antibody (MAB) therapy com pared with dose equivalent external beam irradiation. Continuous expo nentially decreasing low dose rate (LDR) -y-irradiation, and multiply fractionated (MF) \-irradiation were compared with dose equivalent I31IMAH. The relative therapeutic efficacy of radioimmunothe...

The murine B-cell lymphoma 38C13 model was used to study the radiobiological effect of 131I-monoclonal antibody (MAB) therapy compared with dose equivalent external beam irradiation. Continuous exponentially decreasing low dose rate (LDR) gamma-irradiation, and multiply fractionated (MF) X-irradiation were compared with dose equivalent 131I-MAB. The relative therapeutic efficacy of radioimmunot...

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

The dosimetric properties of fast-neutron beams with energies ≤80 MeV were explored using Monte Carlo techniques. Taking into account transport of all relevant types of released charged particles (electrons, protons, deuterons, tritons, 3He and α particles) pencil-beam dose distributions were derived and used to calculate absorbed dose distributions. Broad-beam depth doses in phantoms of differ...

You certainly have noticed that this year Radiation and Environmental Biophysics celebrates its 50-year anniversary (Rühm and Friedl 2013). This is a good opportunity to look back and identify those manuscripts in the journal that later turned out to be of scientific importance for the further developments in radiation research. Of course, the definition of hallmark papers is not as straightfor...

This month’s lead is a summary and review of the National Research Council’s “Toxicity Testing in the 21st Century: A Vision and A Strategy.”1 In this article, Daniel Krewski, Melvin Andersen, Ellen Mantus, and Lauren Zeise summarize a vision to advance toxicity testing and human health assessment of environmental agents. They describe how scientific advances can transform toxicity testing to a...