Introduction: Research has shown that gold nanoparticles (AuNPs) can damage the physiological processes of brain tissue. Given the antioxidant properties of gingerol (GING), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), DNA oxidative damage, and the amount of Bax and Bcl2 apoptosis ...

we have previously shown that the proliferative response of t cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (cr) attenuated the age-related decline in proliferation and il-2 expression. because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...

ischemia reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia reperfusion induces cell death and endemic reaction that is one of the most important clinical problems with acute renal failure and renal transplantation. in this study, the effect of pentoxifylline on rat kidney function and cell injury followi...

Introduction: Cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. The purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. Methods: To induce bilateral cryptorchid model, immature mice were anesthetized and a...

Abstract This study was to investigate whether high-intensity interval training (HIIT) and saffron aqueous extract (SAE) would provide a synergistic effect improve tumor volume reduction also modulate pro- anti-apoptotic protein expression in tissue of 4T1 breast cancer-bearing mice. Female mice following induction cancer through injection cell lines were randomly divided into four groups: (1) ...

objective: in order to improve the water solubility and bioavailability of curcumin in cancer therapy, we prepared and tested a novel waterborne cationic polyurethane (pu) as a nano-carrier for curcumin loading (cu-pu). we studied the effect of this prepared nano-drug on melanoma (f10b16) and fibroblasts cells (l929). methods: morphology, size and cell internalization ability of the prepared n...

BACKGROUND To examine changes of mRNA and protein expressions of MMP-2, Bcl-2, and BAX in atrial fibrillation (AF) patients, and investigate the correlations among these 3 biomarkers. MATERIAL AND METHODS Rheumatic heart disease patients (n=158) undergoing cardiac surgical procedures for mitral valve repair or replacement were included as the AF group (n=123), containing paroxysmal AF (n=42), p...

it has been hypothesized that elevated plasma homocysteine (hcy) plays a role in the pathogenesis of alzheimer’s disease (ad) and age-related cognitive decline. the mechanism of hcy neurotoxicity in the brain is controversial as well hcy is a ligand of nmda receptor. memantine, an uncompetitive antagonist of n-methyl-d-aspartate (nmda) receptors approved for the treatment of moderate to severe ...