The effects of capsaicin and mucosal acidification on gastric HCO3(-) secretion were compared in wild-type and prostacyclin (PGI2) IP receptor or prostaglandin E receptor EP1 or EP3 knockout C57BL/6 mice as well as rats. Under urethane anesthesia, the stomach was mounted on an ex vivo chamber, perfused with saline, and the secretion of HCO3(-) was measured at pH 7.0 using the pH-stat method. Ca...

To examine the mechanism by which mineralocorticoids regulate HCO3- absorption in the rabbit inner stripe of the outer medullary collecting duct, we microfluorometrically measured intracellular pH (pHi) in in vitro perfused tubules using 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) assaying the apical and basolateral membrane H+/OH-/HCO3- transport processes in three groups of animal...

background: acute methanol poisoning is one of the most important chemical poisoning due to drinking of illegal and handmade alcoholic beverages in iran. the aim of this study was to evaluate clinical and biochemical parameters as prognostic factor in acute methanol poisoning. methods: a retrospective study was performed on acute methanol poisoning cases admitted to the loghman hakim hospital p...

In the present study, salinization trends of different soil types from a small hydrographic basin situated in NE Romania (Roșior basin) are investigated. The climatic conditions favorable for long dry summers and intensive evaporation. soils developed on immature evolved clay sediments, as revealed by geochemical analysis. salinity varies among types, attaining maximum values Solonetz with tota...

In this work, Ag2CO3 was prepared via a solution-based method and further characterized by XRD, Raman spectroscopy, SEM/EDS analysis, UV-VIS spectroscopy. SEM results revealed the formation of micro-sized particles with rectangular shape. The photocatalytic activity catalyst evaluated in degradation 4-tert-butylphenol (4-t-BP) under simulated solar light irradiation. effects 4-t-BP initial conc...

The epithelial anion channel CFTR interacts with multiple PDZ domain-containing proteins. Heterologous expression studies have demonstrated that the Na+/H+ exchanger regulatory factors, NHERF1, NHERF2, and PDZK1 (NHERF3), modulate CFTR membrane retention, conductivity, and interactions with other transporters. To study their biological roles in vivo, we investigated CFTR-dependent duodenal HCO3...

Bestrophin-1 (Best1) is a Cl(-) channel that is linked to various retinopathies in both humans and dogs. Dysfunction of the Best1 Cl(-) channel has been proposed to cause retinopathy because of altered Cl(-) transport across the retinal pigment epithelium (RPE). In addition to Cl(-), many Cl(-) channels also transport HCO3(-). Because HCO3(-) is physiologically important in pH regulation and in...

Address for Correspondence:Masaji Mochizuki, Minami-11, Nishi-20, 4-23 Chuo-Ku, Sapporo 064-0811, Japan The bicarbonate concentration in plasma , [HCO3], has a PCO2-dependent component, [HCO3]*, and a metabolic component, [HCO3]. The [HCO3]* in elderly patients and volunteers was expressed by an exponential function of PCO2 obtained by analysis of the venous-arterial (a-v) difference in [HCO3]....

assessing the quality of groundwater is important to ensure the sustainablesafe use of these resources. however, describing the overall water quality condition isdifficult due to the spatial variability of multiple contaminants and the wide range ofindicators (chemical, physical and biological) that could be measured. therefore, in thiscase study, some water quality parameters including na, mg,...