Inducing high magnitude of antibodies with epitope breadth over prolonged periods of time is likely a prerequisite to prevent several of the world’s most serious infectious diseases such as HIV-1, malaria and tuberculosis for which there are no vaccines yet. A much better understanding of the innate immune mechanisms that are critical for inducing strong responses to vaccination is therefore es...

One of the most frequent questions shaping the current influenza season revolves around understanding the benefits and risks of combined vaccination for the seasonal and the pandemic strains. Influenza viruses stand out as one of the most important pathogens in terms of the morbidity and mortality they caused throughout history. Annually, seasonal influenza claims over 36,000 deaths in the Unit...