A 25-YEAR-OLDwhitemanpresentedwithalifelong history of severe, sometimes excruciatingpain inhis legs,whichwereconstantly red and hot. He insisted on having his legs and feet constantly in ice water to relieve his severe discomfort. He required treatment with oxycodone and acetaminophen (Percocet) every 4 hours for pain. His mother recalled that from the age of 2 years his feet and legs intermit...

There are limited data on the effects of Class IB and IC antiarrhythmic drug combination for the treatment of ventricular tachycardia. The present study evaluated this combination in 12 patients who had sustained ventricular tachycardia (SuVT) during programmed electrical stimulation (PES) and failed IC antiarrhythmic therapy. Following combination of lidocaine and a IC agent (7 with encainide ...

We report a detailed case of type 2 TS due to p.(Gly402Ser) mutation in exon 8 the CACNA1C gene. The patient shows marked prolongation repolarization with mean QTc 540 ms. He no structural heart disease, syndactyly, or cranio-facial abnormalities. However, he developmental delays, without autism, and dental cardiac phenotype is very severe, resuscitated arrest at 2.5 years age, followed by 26 a...

The congenital long QT syndrome (LQTS) is an inherited disorder characterized by a delay in cardiac cellular repolarization leading to cardiac arrhythmias and sudden death often in young people. One form of the disease (LQT3) involves mutations in the voltage-gated cardiac sodium channel. The potential for targeted suppression of the LQT defect was explored by heterologous expression of mutant ...

We studied the antiarrhythmic effects of NS-2 (4-diisobutylamino-1,1-diphenyl-1-butanol maleate) and AFD-19 (active metabolite of NS-2) on early stage ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized male rats. These effects were compared with those of disopyramide and mexiletine. Drugs were intravenously administered either before or after coronary o...