The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.

BACKGROUND Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in humans, and the methylation pattern demonstrates large interindividual differences. The fraction of urinary MMA is a marker for susceptibility to As-related diseases. OBJECTIVES We evaluated the impact of polymorphisms in five methyltransferase genes on As metabolism in two populations, one in Sou...

Circular RNA is crucial for the development of multiple malignant tumors including colorectal cancer. lamin B1 has recently been verified to accelerate cancer progression. However, it not clear whether circular can be regulated by main methylase (methyltransferaselike 3) in This study was explore mechanism methyltransferase-like 3-mediated epigenetic reactivation We first analyzed expression an...

Abstract Microorganisms release small volatile metabolites with unique structures, e. g. the polymethylated homosesquiterpene sodorifen from Serratia plymuthica . Two unusual enzymes novel features are involved in its biosynthesis, a C -methyltransferase cyclization activity and terpene synthase that accepts non-canonical monocyclic 16 substrate. The class of methyltransferases represents an al...

The purine alkaloid theacrine, synthesized in a high amount Kucha (Camellia kucha (Chang et Wang) Chang), has shown multiple pharmacological effects such as anti-depression, dehydration and hypnotic activities. It is critical to better understand the theacrine metabolism at molecular level for future breeding programs. To identify putative genes involved biosynthesis, we carried out comparative...