نتایج جستجو برای: methylene tetrahydrofolate dehydrogenase mthfd1
تعداد نتایج: 88908 فیلتر نتایج به سال:
382 Gene polymorphism of 5, 10-methylene tetrahydrofolate reductase is related to boar semen quality
BACKGROUND Folate and methionine metabolism is involved in DNA synthesis and methylation. Polymorphisms in the genes of folate metabolism enzymes have been associated with some forms of cancer. In the present study, 2 polymorphisms were evaluated for a folate metabolic enzyme, methylene-tetrahydrofolate reductase (MTHFR), and one was evaluated for methionine synthase (MS). The 2 polymorphisms M...
BACKGROUND AND PURPOSE Quantitative predictions of the risk of cerebral venous thrombosis (CVT) conferred by certain genotypes have yet to be reliably established. We conducted a comprehensive meta-analysis of all candidate genes studied to assess their genetic contribution to the etiology of CVT. We compared our findings against equivalent analyses for pediatric CVT and adult ischemic stroke. ...
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
In thymidylate synthase (TS), the invariant residue Asp-221 provides the only side chain that hydrogen bonds to the pterin ring of the cofactor, 5,10-methylene-5,6,7,8-tetrahydrofolate. All mutants of D221 except cysteine abolish activity. We have determined the crystal structures of two ternary complexes of the Escherichia coli mutant D221N. In a complex with dUMP and the antifolate 10-proparg...
We investigated the association between methylenetetrahydrofolate reductase (gene MTHFR 677C>T, rs1801133), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR 2756A>G, rs1805087), and dehydrogenase, cyclohydrolase formyltetrahydrofolate synthetase 1 MTHFD1 1958G>A, rs2236225)—well-studied functional variants involved in one-carbon metabolism—and gynecologic cancer risk, inter...
284 Gene polymorphism of 5, 10-methylene tetrahydrofolate reductase is related to boar semen quality
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