The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...

Isocyanate impregnation was studied relative to the subterranean termite (Coptotermes curvignathus Holmgren) resistance of inner part oil palm (Elaeis guineensis Jacq.) trunk. Unproductive trunk harvested and divided into top bottom parts. Samples were isolated from with a size 2.5 cm x 0.5 cm. The samples impregnated 10% 20% aqueous polymer-isocyanate then heated at 60 °C for 48 h. specimens f...

A new synthetic approach to the preparation of intramolecularly collapsed nanoparticles under mild, room temperature conditions has been developed from commercially available vinyl monomers. Reaction of isocyanate functionalized linear copolymers with a diamine in dilute solution leads to the efficient formation of nanoparticles where the diameter of the nanoparticle can be varied by controllin...

The catalytic CO + NO reaction to form CO2, N2, and N2O has been studied on a Pd(111) surface at pressures up to 240 mbar using in situ polarization modulation infrared reflection absorption spectroscopy (PM-IRAS). At 240 mbar, for a pressure ratio of PCO:PNO = 3:2 and under reaction conditions, besides adsorbed CO, the formation of isocyanate (-NCO) was observed. Once produced at 500-625 K, th...

Epigenetic process are one of the most diverse & dynamic concept, which is controlled by a group various highly specialized cellular events like DNA methylation (5-methyl cytosine, 5-hydroxymethyl cytosine, 5-fluoro Cytosine, 5-carboxyl cytosine), histone modification (acetylation, methylation, phosphorylation, sumoylation, biotinylation, citrulination, ubiquitinylation, krotonilation, isomeriz...

Groups of ten male and ten female Fischer 344 rats were exposed by inhalation 3.1, 0.6, 0.15, or 0.0 (control) ppm of methyl isocyanate (MIC) vapor 6 hr per day for 8 days (two 4-day sessions separated by a 2-day rest). Evaluation of toxic effects included body weight, food consumption, organ weights, and selected hematologic, ophthalmic, neurologic, gross anatomic, and histologic examinations....

Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journals for several months after the accident. We therefore conducted, 9 months afte...

Tanser, A. R., Bourke, M. P., and Blandford, A. G. (1973). Thorax, 28, 596-600. Isocyanate asthma: respiratory symptoms caused by diphenyl-methane di-isocyanate. We investigated 57 employees of a factory where diphenyl-methane di-isocyanate (MDI) was used to prepare the materials for making rigid polyurethane foam. Four employees had developed hypersensitivity to MDI. Two had severe, and one mo...

BACKGROUND Isocyanate exposure is the most common cause of work-related asthma. In 2003, a male in his mid-40s died of an acute asthmatic reaction approximately 1 hr after he sprayed the inside of a cargo van with an isocyanate-containing truck bedliner. This is the first reported death attributable to this type of isocyanate application. METHODS The Michigan Fatality Assessment and Control E...