Multidrug resistance (MDR) is a severe obstacle to successful chemotherapy due to its complicated nature that involves multiple mechanisms, such as drug efflux by transporters (P-glycoprotein and breast cancer resistance protein, BCRP) and anti-apoptotic defense (B-cell lymphoma, Bcl-2). To synergistically and completely reverse MDR by simultaneous inhibition of pump and non-pump cellular resis...

Increasing cost pressures have led supply chain managers to focus on running increasingly lean and efficient supply chains, with minimal inventory. Indeed, more and more firms are relying on pull or make-toorder (MTO) supply chains to minimize cost and waste. At the same time, increasing competitive pressures are leading to an increased emphasis on customer service. An important element of cust...

The number of people suffering from symptoms sensitive skin has been growing. Their main pains are specified as dryness and chronic itch. Recent studies showed that Substance P (SP) Neurokinin 1 receptor (NK1R) on the C nerve fibers related to Focusing this pathway, we discovered maltotetraose (MTO), a type polysaccharide, alleviated itch skin. Single-center, open-label clinical trials formulat...

Fabrication of hierarchical porosity in microporous zeolites is a key to overcoming the inherent mass-transfer limitation and improving molecular accessibility active sites. The present study reports facile cost-effective etching strategy based on crystal metastability construct SAPO-34 (CHA-type) zeolite. with high crystallinity obtained conveniently via an extended hydrothermal treatment with...

abstract: in this study an appropriate computational approach was presented for estimating the boiling temperatures of 41 different types of olefins and their derivatives. based on the guidelines of this approach, several structural indices related to the organic components were applied using graph theory. meanwhile, in addition to evaluating the relation between the boiling temperatures of ole...

Abstract: In this study an appropriate computational approach was presented for estimating the boiling temperatures of 41 different types of olefins and their derivatives. Based on the guidelines of this approach, several structural indices related to the organic components were applied using graph theory. Meanwhile, in addition to evaluating the relation between the boiling temperatures of ole...

The number and the strength of acid sites in catalysts have paramount importance on their efficiency. In zeolites chemistry, increased content framework Al gives a higher strong sites. Their can be disadvantage catalytic reactions (e.g., methanol to olefins conversion) due undesired secondary coke formation. Here, Faujasite type zeolite with has been used for investigating role defects structur...