The effects of repeated administration of morphine and methadone, followed by a challenge dose of either morphine or methadone were examined ex vivo in rat frontal cortical slices that were prepared 1 h after final drug administration. Morphine challenge dose (5 mg/kg), administered 14 days after the end of repeated morphine pretreatment (10 mg/kg, administered 7 times) decreased both the AMPA/...

Whilst unsupervised injectable methadone and diamorphine treatment has been part of the British treatment system for decades, the numbers receiving injectable opioid treatment (IOT) has been steadily diminishing in recent years. In contrast, there has been a recent expansion of supervised injectable diamorphine programs under trial conditions in a number of European and North American cities, a...

how to cite this article: jabbehdari s, farnaghi f, shariatmadari sf, jafari j, mehregan ff, karimzadeh p. accidental children poisoning with methadone: an iranian pediatric sectional study. iran j child neurol. 2013 autumn;7(7): 32-34. objective toxic poisoning with methadone is common in children in iran. our study was carried out due to the changing pattern of methadone poisoning in recent y...

QUESTION One of my patients is currently using methadone for maintenance of opioid dependence. She wants to breastfeed. Is breastfeeding safe for her infant? ANSWER The exposure of infants to methadone through their mothers' breast milk is minimal. Women using methadone for treatment of opioid dependence should not be discouraged from breastfeeding. The benefits of breastfeeding largely outwe...

BACKGROUND Opioid maintenance treatment is the option of choice to stabilize opioid-dependent patients. Whilst efficacy of methadone and buprenorphine has been studied extensively, fewer data on slow-release oral morphine are available. AIMS This study analyzes the effects of slow-release oral morphine compared to methadone with regard to self-reported mental symptoms, drug use and satisfacti...

AIMS To evaluate the efficacy and safety of methadone versus buprenorphine treatment in pregnant opioid-dependent women. DESIGN Randomized, double-dummy, double-blind, flexible-dosing comparison study. SETTING Addiction Clinic at the Medical University of Vienna, Austria. PARTICIPANTS Eighteen women were assigned randomly to receive either methadone (n = 9) or buprenorphine (n = 9) during...

AIMS Evaluation of the efficacy and safety of slow-release oral morphine (SROM) compared with methadone for detoxification from methadone and SROM maintenance treatment. DESIGN Randomized, double-blind, double-dummy, comparative multi-centre study with parallel groups. SETTING Three psychiatric hospitals in Austria specializing in in-patient detoxification. PARTICIPANTS Male and female op...

Purpose. Methadone, a synthetic opioid agonist, is an effective alternative to strong opioids (morphine, hydromorphone, oxycodone, and buprenorphine) and is widely available as an oral formulation. Few data have been published so far on the use of intravenous (i.v.) methadone for the management of severe or refractory cancer pain. Methods. We followed 10 consecutives cancer patients with severe...