نتایج جستجو برای: metformin hyperinsulinemia
تعداد نتایج: 16815 فیلتر نتایج به سال:
BACKGROUND Metformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known. METHODS To evaluate whether metformin induces anorexia via the hypothalamus, various concentrations of metformin were injected into the lateral ventricle of rats through a chronic...
AIM The study aim was to evaluate the efficacy and safety of initial combination therapy with saxagliptin + metformin vs. saxagliptin or metformin monotherapy in treatment-naïve patients with type 2 diabetes (T2D) and inadequate glycaemic control. METHODS In this multicentre, randomized, double-blind, active-controlled phase 3 trial, 1306 treatment-naïve patients with T2D >or=18 to <or=77 yea...
45 46 Adding metformin to exercise does not augment the effect of training alone to boost whole-body insulin 47 sensitivity and lower circulating insulin concentrations. While lower insulin concentrations (lower 48 supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in 49 insulin secretion that match increases in peripheral insulin sensitivity...
BACKGROUND To evaluate the efficacy and safety of glyburide/metformin combined tablet compared to glyburide or metformin alone in patients with type 2 diabetes. METHODS In this 16-week, multicenter, randomized, double-blind, 4-arm and parallel clinical trial study, 100 patients with type 2 diabetes mellitus were recruited and 76 patients were available for statistical analysis at the end of t...
Background and Objective: Diabetes mellitus (DM) in long-term is associated with learning and memory decline. Metformin is an anti-diabetic drug with antioxidant and memory-improving effects. Thus, this research study was conducted to assess the effect of metformin on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly assign...
Background and Objective: Different pharmaceutical types of metformin are available for glycemic control in type 2 diabetes mellitus. There is some doubt about the efficacy of metformin produced by domestic pharmaceutical companies. As a clinical trial, we compared the efficacy and complications of metformin produced by an Iranian company with metformin from a Canadian company in diabetic patie...
BACKGROUND Metformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferation in several human cancers and inhibits the Warburg phenomenon in tumor cells. RESULTS Low PDH levels were observed in OSCC, and Metformin promotes an increase in PDH levels in hypoxic conditions. Me...
Background Metformin reduces the risk of, and mortality from, colorectal cancer in patients with diabetes mellitus. However, effect of metformin on stage IV disease is unknown. In present study we reviewed clinical features outcomes mellitus (M1, liver metastases) treated or without metformin.
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