Metered-dose inhalers (MDIs) are currently being reformulated to contain hydrofluoroalkanes (HFAs), which do not damage the Earth's ozone layer. As different formulations of inhaled drugs may behave differently when used with spacer devices, we wished to determine the amount of salbutamol available for inhalation from a conventional metered-dose inhaler (Ventolin) and a new HFA-containing formu...

Definition of chronic obstructive generally agreed that the bronchodilation obpulmonary disease tained is largely a reflection of the dose of In this paper the term “chronic obstructive bronchodilator administered rather than the pulmonary disease” (COPD) is used as defined mode of administration. It is therefore unlikely in the forthcoming British Thoracic Society that treatment with either a ...