BACKGROUND & OBJECTIVES Acinetobacter baumannii can cause a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis, etc. This organism is becoming resistant to a large group of antibiotics, especially β-lactam antibiotics. The reason for multi-drug resistance may be the production of extended- spectrum β-lactamses (ESBLs), carbapenemases/metallo β-lactam...

Carbapenemases have great importance in the global epidemiological scenario since infections with carbapenemase-producing bacteria are associated with high mortality, especially in hospitalized patients in intensive care units. This study describes two microorganisms producers of the New Delhi Metallo-b-lactamase, Klebsiella pneumoniae and Citrobacter freundii, from two patients admitted to a p...

background: acinetobacter baumannii is gram- negative opportunistic coccobacilli, the most important agent in nosocomial infections with high mortality rate. multidrug resistance in strains isolated from nosocomial infections , making it difficult to treat and sometimes impossible. the aim of the present study was to investigate antibiotic resistance in a. baumannii isolates from iranian patien...

conclusions beside our study, the detection of mbl genes were reported in a few studies conducted in iran. the spread of detected mbls producing p. aeruginosa were unprecedented in the region due to the lack of independent related researches or the novel incidence of these genes. this detection must be noted by associated clinical and health care services. results from 240 p. aeruginosa isolate...

The obtaining of nanocarriers gene material and small drugs is still an interesting research line. Side-effects produced by the toxicity several pharmaceutics, high concentrations needed to get therapeutic effects, or their excessive use patients have motivated search for new nanostructures. For these reasons, cationic metallo-liposomes composed phosphatidylcholine (PC), cholesterol (CHO) RuC1C...

OBJECTIVES Pseudomonas putida is an uncommon opportunistic pathogen, usually susceptible to antimicrobial agents. Data concerning resistance to antimicrobial agents in clinical P. putida isolates are limited. PATIENTS AND METHODS Susceptibilities to fluoroquinolones, carbapenems and other antibiotics were characterized in five clinical isolates of P. putida recovered from different patients w...

The metallo-beta-lactamase produced by Chryseobacterium (formerly Flavobacterium) meningosepticum, which is the flavobacterial species of greatest clinical relevance, was purified and characterized. The enzyme, named BlaB, contains a polypeptide with an apparent Mr of 26000, and has a pI of 8.5. It hydrolyses penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicill...

The reactions between [Pd(P-P)(OTf)2] (where P-P=dppp or dppf) and two different bipyridyl ligands (=1,3-bis(4-pyridylmethyl)urea and=1,3- bis(pyridinylmethyl)benzenedicarboxamide) containing hydrogen-bonding units have been studied. The X-ray crystal structures of three of these assemblies have been solved showing them to be the [2+2] metallo-macrocycles [Pd(P-P)(n)]2(OTf)4 [P-P=dppp, n=1, ();...

New Delhi metallo-β-lactamase-1 (NDM-1) producing Escherichia coli constitute a serious threat to global health since it is found to be highly resistant to most of the currently available antibiotics including carbapenems. Gram-negative bacterial strains with NDM-1 (New Delhi Metallo-beta-lactamase-1) gene, also called the superbug, detected in Ganges water. The New Delhi metallo-β-lactamase (N...

conclusions the results of this study show that the rate of p. aeruginosa-caused burn wound infections was very high, and many of the isolates were resistant to three or more classes of antimicrobials. such extensive resistance to antimicrobial classes is important because few treatment options remain for patients with burn wound infections. blaimp-producing p. aeruginosa isolates are a rising ...