We have developed a computational method that predicts the positions of active compounds, making it possible to increase activity as a fragment evolution strategy. We refer to the positions of these compounds as the active position. When an active fragment compound is found, the following lead generation process is performed, primarily to increase activity. In the current method, to predict the...

Unlike digitally savvy banking and retail industries, oil and natural gas businesses are latecomers to digitization. With large capital investments in complex industrial operations, firms in latecomer industries are seeking ways to cut costs and become responsive to market demands. Executives in oil and natural gas companies are facing unprecedented pressure to cut costs due to market turbulenc...

We present a design and test strategy for Geometric Primitive Shadersintegrated circuits which perform rasterisation of primitives such as vectors and triangles. The design strategy proceeds through various levels of detail, and we describe the need for testing as the design advances. A suitable set of test are given for a typical shader. Our experiences in applying the strategy to a real devic...

Implementing the Comprehensive Africa Agriculture Development Programme (CAADP) as the centerpiece of a poverty-reduction strategy implies that agriculture and its individual subsectors must play a primary role as leading sources of pro-poor growth at national level. Uganda and other African countries pursuing the CAADP agenda are not just seeking to accelerate growth but also to maximize and b...

This paper presents a performance analysis of the recently proposed σ-self-adaptive weighted recombination evolution strategy (ES) with scaled weights. The steady state behavior of this ES is investigated for the non-noisy and noisy case, and formulas for the optimal choice of the learning parameter are derived allowing the strategy to reach maximal performance. A comparison between weighted mu...

Batie et al. [Chemistry and Biochemistiv, of "avoenzymes, 3, 543-556 (1991)] proposed a classification system for ring-hydroxylating oxygenases in which the oxygenases are grouped into three c)asses in terms of the number of constituent components and the nature of the redex centers. But in recent years, many ringhydroxylating oxygenases haye been newly identified and characterized, and found d...

BACKGROUND Community members, Aboriginal organizations, public servants and academics have long been describing a desperate situation of food insecurity in the Eastern Canadian Arctic. OBJECTIVE The Nunavut Food Security Coalition, a partnership of Inuit Organizations and the Government of Nunavut, is collaborating to develop a territorial food security strategy to address pervasive food inse...

The Duality of IT There’s a duality to IT that creates dilemmas for business leaders. This duality, manifest in the following five forms, gives IT the power to reshape the strategic agenda of organizations. First, IT enables both sustaining and disruptive innovation. Thus, a key strategic issue for digital business strategists involves discerning whether an IT innovation is sustaining, disrupti...

Recent reports of training-induced gains on fluid intelligence tests have fueled an explosion of interest in cognitive training-now a billion-dollar industry. The interpretation of these results is questionable because score gains can be dominated by factors that play marginal roles in the scores themselves, and because intelligence gain is not the only possible explanation for the observed con...

Investigators often have multiple suspects to interview in order to determine whether they are guilty or innocent of a crime. Nevertheless, co-offending has been significantly neglected within the deception detection literature. The current review is the first of its kind to discuss co-offending and the importance of examining the detection of deception within groups. Groups of suspects can be ...