Objective(s): The molecular basis of “metabolically healthy obese” and “metabolically unhealthy non-obese” phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese (metabolically healthy vs unhealthy (MHNO vs MUHNO)) individuals. Materials ...

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

abstract three separate greenhouse experiments were conducted in the greenhouse facilities of the iranian plant protection research institute, tehran, to study the efficacy of some accase inhibiting herbicides for control of resistant based on mechanism, resistance based on enhanced metabolism and susceptible wild oat biotypes. in each experiment, biotypes were treated separately by 17 herbicid...

phosphate (p) is one of the key substrates in energy metabolism and biosynthesis of nucleic acids and membranes. in order to identify molecular mechanisms involved in rice adaptation to p deficiency, we applied a proteomic approach to compare a rice parental line, nipponbare (sensitive), and its near isogenic line (nil6-4) (resistant). the experiment was conducted using a completely randomized ...

the present study was conducted to test the effect of origanum majoranum extract (ome) of leaves on alterations induced in a model of type 2 diabetic rats. adult male wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. diabetic rats were given aqueous extract of ome in a dose of 20 mg/kg orally ...

Aged refuse is widely considered to have certain soil fertility. 16S rRNA amplicon sequencing used investigate the microbial community of aged refuse. The found contain higher fertility elements (total nitrogen, total phosphorus, potassium, etc.) and concentrations heavy metals (Pb, Cd, Zn, Hg). Taxonomy based on operational taxonomic units (OTUs) shows that Actinobacteria, Proteobacteria, Chlo...