1. The ventilatory response to severe metabolic acidosis was studied by measuring arterial blood carbon dioxide tension and pH in sixty-seven patients with blood pH less than 7-10, none of whom had hypercapnia, pulmonary oedema, or chronic pulmonary insufficiency. The results were compared with those previously found in patients with uncomplicated diabetic ketoacidosis. 2. By that comparison, f...

The immediate local metabolic response of the myocardium to acute regional ischemia is determined by an interaction of various influences. These include: (1) the extent of and the variability in reduction of blood flow; (2) the degree and persistence of hypoxia; and (3) the effects of local release of catecholamines, particularly in relation to loss of intracellular potassium. The subsequent me...

The immediate local metabolic response of the myocardium to acute regional ischemia is determined by an interaction of various influences. These include: (1) the extent of and the variability in reduction of blood flow; (2) the degree and persistence of hypoxia; and (3) the effects of local release of catecholamines, particularly in relation to loss of intracellular potassium. The subsequent me...

LIPMAN, R. L., F. ULVEDAL, W. K. BROWN, S. D. LEVERETT, F. R. LECOCQ and J. J. SCHNURE. Metabolic response to acceleration in man. Aerospace Med. 41 (3) :905-90B. 1970. The glucose analogue 2-deoxy-I)-glucose {2-1X5) was used as a means of producing intracellular bypoglycemia in eight normal male volunteer subjects during a control period, immediately following their initial exposure to acceler...

The immediate local metabolic response of the myocardium to acute regional ischemia is determined by an interaction of various influences. These include: (1) the extent of and the variability in reduction of blood flow; (2) the degree and persistence of hypoxia; and (3) the effects of local release of catecholamines, particularly in relation to loss of intracellular potassium. The subsequent me...

Blood concentrations of glycerol and free fatty acids were measured in healthy and sick 5-day-old infants during and after cold exposure. In apparently similar infants in similar circumstances, the blood concentrations varied widely. Although the concentrations of both glycerol and free fatty acids tended to be higher during cold exposure, it is not possible to use either as an index of cold ex...

We studied cerebral oxygenation and metabolism during submaximal cycling in 12 subjects. At two work rates, middle cerebral artery blood velocity increased from 62 +/- 3 to 63 +/- 3 and 70 +/- 5 cm/s as did cerebral oxygenation determined by near-infrared spectroscopy. Oxyhemoglobin increased by 10 +/- 3 and 25 +/- 3 micromol/l (P < 0. 01), and there was no significant change in brain norepinep...

The immediate local metabolic response of the myocardium to acute regional ischemia is determined by an interaction of various influences. These include: (1) the extent of and the variability in reduction of blood flow; (2) the degree and persistence of hypoxia; and (3) the effects of local release of catecholamines, particularly in relation to loss of intracellular potassium. The subsequent me...

BACKGROUND In the phase III MPACT trial, nab-paclitaxel plus gemcitabine (nab-P + Gem) demonstrated superior efficacy versus Gem alone for patients with metastatic pancreatic cancer. We sought to examine the feasibility of positron emission tomography (PET) and to compare metabolic response rates and associated correlations with efficacy in the MPACT trial. PATIENTS AND METHODS Patients with ...

The metabolic and temperature response to mild cold were investigated in summer and winter in a moderate oceanic climate. Subjects were 10 women and 10 men, aged 19-36 years and BMI 17-32 kg/m2. Metabolic rate (MR) and body temperatures were measured continuously in a climate chamber with an ambient temperature of 22 degrees C for 1 h and subsequently 3 h of 15 degrees C. The average metabolic ...