نتایج جستجو برای: metabolic profiling
تعداد نتایج: 296594 فیلتر نتایج به سال:
The current developments in metabolomics and metabolic profiling technologies have led to the discovery of several new metabolic biomarkers. Finding metabolites present in significantly different levels between sample sets, however, does not necessarily make these metabolites useful biomarkers. The route to valid and applicable biomarkers (biomarker qualification) is long and demands a signific...
Despite many developed experimental and computational approaches, functional gene annotation remains challenging. With the rapidly growing number of sequenced genomes, the concept of phylogenetic profiling, which predicts functional links between genes that share a common co-occurrence pattern across different genomes, has gained renewed attention as it promises to annotate gene functions based...
Osteoarthritis (OA) is a debilitating disease associated with pain and loss of function in numerous diarthrodial joints of the body. Assessments of the severity and/or progression of OA are commonly based on radiographic stages and pain level, which aren't always correlated to severity of disease or joint dysfunction and may be confounded by other factors(1). There has been recent interest in i...
Metabolic phenotyping at cellular resolution may be considered one of the challenges in current plant physiology. A method is described which enables the cell type-specific metabolic analysis of epidermal cell types in Arabidopsis thaliana pavement, basal, and trichome cells. To achieve the required high spatial resolution, single cell sampling using microcapillaries was combined with routine g...
M etabolomics (also referred to as metabonomics) is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissue, and body fl uids. The study of metabolism at the global or "-omics " level is a new but rapidly growing fi eld that has the potential to have an impact upon medical practice [1–4]. At the center of metabolomics is the concep...
Metabolic profiling applied to functional genomics (metabolomics) is in an early stage of development. Here, the technologies used for metabolite profiling are briefly covered, illustrated by a few pioneering studies. Issues related to bioinformatics, namely data analysis, visualisation and archival, are the main focus of this review. Arguably there is already a need for databases containing me...
Lipids are heterogeneous biological molecules that possess multiple physiological roles including cell structure, homeostasis, and restoration of tissue functionality during and after inflammation. Lipid metabolism constitutes a network of pathways that are related at multiple biosynthetic hubs. Disregulation of lipid metabolism can lead to pathophysiological effects and multiple lipid mediator...
normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the aim of this study is to look for the proper methods that would be a major step towards untreated cd diagnosis and seek the metabolic biomarkers causes of cd and compare them to control group. background : celiac disease (cd) is a common autoimmune disorder that is not easily diagnosed using the clinical tests. patie...
بیماری های زیادی در دنیا، بسته به شرایط اقلیمی گیاه کلزا را مورد تهدید قرار می دهد و باعث وارد آمدن خسارت اقتصادی به آن می گردد. موثرترین روش برای کنترل بیماری، اصلاح برای مقاومت می-باشد، به طوریکه توارث ژنتیکی کافی موجود باشد. بنابراین، بررسی تنوع ژنتیکی ژرم پلاسم موجود، یکی از روش های مناسب مدیریت منابع ژنتیکی می باشد. روشnbs profiling موتیف های محافطت شده در دمین های عملکردی خانواده ژنی را م...
BACKGROUND Lower birthweight is associated with increased susceptibility to cardiometabolic diseases in adulthood, but the underlying molecular pathways are incompletely understood. We examined associations of birthweight with a comprehensive metabolic profile measured in adolescents and adults. METHODS High-throughput nuclear magnetic resonance metabolomics and biochemical assays were used t...
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