Malignant ectomesenchymoma is a rare tumor that contains both ectodermal and mesenchymal elements. So far, only 7 patients with a manifestation in the cerebrum (with confirmed clinicopathological data) have been reported. A 4-year-old girl was present at our hospital with a 3-week history of intermittent sudden dizzy with no apparent cause. MRI showed an irregular enhanced lesion in the left fr...

Mesenchymal tumor of the esophagus is rare, and the most common mesenchymal tumor of the esophagus is leiomyoma [1-3]. The incidence of esophageal leiomyoma from autopsy cases ranges from 0.005 to 5% [2, 3]. Although detailed histopathological examination of autopsy and surgically resected case series demonstrated that its incidence is higher at 7.9% [1]. This disease is typically found in pati...

Mesenchymal chondrosarcoma is a rare tumor that is distinctly different from classic chondrosarcoma. The prognosis of this tumor is poor, with a high incidence of locoregional and distant metastases. It shows a predilection for the head and neck, however mesenchymal chondrosarcoma of hyoid bone has rarely been reported. We experienced a case of mesenchymal chondrosarcoma of the hyoid bone in a ...

RATIONALE Mesenchymal hamartomas of the liver is one type of rare liver tumor. PATIENT CONCERNS Mesenchymal hamartomas of the liver (MHL) is rarely reported in the left lobe of the liver in children who are more than 2 years old. It is difficult to distinguish it from liver lesions such as hepatoblastoma in children, and hepatocellular carcinoma and focal nodular hyperplasia in adults. In add...

Phosphaturic mesenchymal tumor (PMT) is a rare and small tumor leading to oncogenic osteomalacia and deriving mostly from benign mesenchymal origin. The tumor may originate in any part of the body such as soft tissue or bone site, but is more frequent in the upper and lower extremities and craniofacial sinuses. Its most common type is oncogenic osteomalacia (OO) associated phosphaturic mesenchy...

Hyaluronan (HA), a principal constituent of the extracellular matrix (ECM), mediates growth and metastasis of tumor cells. The role of HA in the epithelial-mesenchymal transition (EMT) is well known, and increased ECM remodeling is observed in mesenchymal-like cells. The HA synthesis inhibitor 4-methylumbelliferone (4-MU) is anti-tumorigenic for various malignant tumors. However, the antitumor ...

A key cellular process associated with the invasive or metastatic program in many cancers is the transformation of epithelial cells toward a mesenchymal state, a process called epithelial to mesenchymal transition or EMT. Actin-dependent protrusion of cell pseudopodia is a critical element of mesenchymal cell migration and therefore of cancer metastasis. However, whether EMT occurs in human can...

Solid tumors are complex organ-like structures. The potential of normal neighboring cells to contribute to the initiation, progression, and metastasis of epithelial-derived carcinomas has long been appreciated. However, the role of host cells has proven complex. Through multiple local and systemic mechanisms, nontransformed host cells can promote transition from a tumor-resistant to tumor-permi...