BACKGROUND The purpose of this study was to evaluate lymphatic drainage patterns of head and neck cutaneous melanoma observed on preoperative lymphoscintigraphy and sentinel lymph node biopsy (SLNB) and determine discordancy from clinically predicted lymphatic drainage patterns. METHODS We conducted a retrospective chart review of 114 patients with head and neck cutaneous melanomas evaluated ...

Analysis of hydrologic, geomorphic, and suburbanization data from a small instrumented drainage basin near Iowa City, Iowa, indicates that channel networks are radically altered when suburban development overtakes a drainage basin. Changes in channel networks are such that the network becomes much more efficient in collecting water quickly, so that lag time and kurtosis of storm hydrographs are...

A major emphasis in geomorphology over the past six decades has been on the development of quantitative physiographic methods to describe the evolution and behavior of surface-drainage networks (Horton 1945; Leopold & Maddock 1953; Leopold & Wolman 1957; Abrahams 1984). These parameters have been used in various studies of geomorphology and surface-water hydrology, such as flood characteristics...

Effective gas management is vital to the success of the longwall mining in the Bulli seam, in the Southern Coalfield, Sydney Basin, NSW, Australia. The evolution of gas drainage methods and practices are discussed with respect to gas type, gas drainage lead time and prevailing geological conditions. Both underground to inseam drilling and surface to inseam drilling techniques are described at b...

Hypsometry (frequency distribution of elevations) is often used to characterize landscape morphology, traditionally in the context of the degree of fluvial dissection. Recently, the hypsometry of glaciated regions has been used to infer how rates of glacial erosion compare with tectonic uplift rates. However, many factors other than tectonics can also exert a major influence on the hypsometry o...

The regional lymph nodes are commonly the first site of melanoma metastasis. Even within a nodal basin, there may be regional spread to surrounding lymph nodes before progression to distant sites. Therefore, surgical excision of regional lymph nodes has been a focus of melanoma treatment for decades. There are three potential goals of surgery, any one of which may justify the procedure for an i...

BACKGROUND Unusual metastatic presentation of intra-ocular melanoma. STUDY DESIGN Case report. DISCUSSION Extra-regional lymphatic spread of intra-ocular melanoma has not been reported previously in the literature. The usual pattern of metastasis for intra-ocular melanoma is hematogenous. There are few reports of regional spread to the maxillofacial bones. We report an interesting case of a...

Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...