Program Number: 13 Poster Board Number: A0001 Presentation Time: 8:30 AM–10:15 AM Immunohistochemical observation of meibomian gland following ocular surface alkali burning in wild-type and Smad3-deficient mice Shin Mizoguchi1, Yuka Okada1, Reiko Arita2, Shizuya Saika1. 1Ophthalmology, Wakayama Medical University, Wakayama, Japan; 2Ophthalmology, Itoh Clinic, Saitama, Japan. Purpose: To immunoh...

tetracyclines are broad spectrum antibiotics which are inexpensive and widely available and have an appropriate safety profile. in addition to antibiotical effects, tetracyclines can inhibit matrix metaloproteinase and collagenase, and subsequently reduce inflammation, angiogenesis, and neovascularization. they have partial neuro-protective, anti-apoptotic and antioxidant properties. given thes...

Meibomian gland carcinomas are very rare and constitute 1% of all malignant tumors of the eye lid. They are often mistaken for Chalazion and excised. It’s malignant nature being recognized only when it recurs repeatedly. They are locally invasive and metastasize to liver brain and lymph nodes. A case of adenocarcinoma of meibomian sebaceous gland with post operative metastases to parotid gland ...

Recently, we reported obtaining tomograms of meibomian glands from healthy volunteers using commercial anterior segment optical coherence tomography (AS-OCT), which is widely employed in clinics for examination of the anterior segment. However, we could not create 3D images of the meibomian glands, because the commercial OCT does not have a 3D reconstruction function. In this study we report th...

We have established a serum-free clonal culture system to study the growth and differentiation of individual progenitor epithelial cells of the meibomian gland independent of other cell types and undefined serum factors. Single meibomian gland epithelial cells were obtained by subjecting whole meibomian glands to a brief EDTA treatment, needle aspiration, and nylon mesh filtration. The cells ha...

Purpose. We hypothesize that growth hormone (GH) plays a significant role in the regulation of the meibomian gland. To test our hypothesis, we examined the influence of GH on mouse meibomian gland structure. Methods. We studied four groups of mice, including (1) bovine (b) GH transgenic mice with excess GH; (2) GH receptor (R) antagonist (A) transgenic mice with decreased GH; (3) GHR knockout (...

There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of...