Purpose: The objective of this study was to design a cost optimization model that offers production improvement for SMEs. Theoretical framework: Several studies related system disruption management have been conducted, with the majority focusing on large companies. However, small and medium enterprises (SMEs) limitations compared Repairability is considered optimization. Design/methodology/appr...

level: intermediAte Most biopharmaceutical production platforms are based on fed-batch cell culture protocols, which can support high volumetric productivity while maintaining low operational complexity (1). The industry is interested in developing or refining high-titer cell culture processes to meet increasing market demands and reduce manufacturing costs (2). Although advancements in cell en...

level: intermediAte Most biopharmaceutical production platforms are based on fed-batch cell culture protocols, which can support high volumetric productivity while maintaining low operational complexity (1). The industry is interested in developing or refining high-titer cell culture processes to meet increasing market demands and reduce manufacturing costs (2). Although advancements in cell en...

background and objectives: acetic acid bacteria (aab) are useful in industrial production of vinegar. the present study aims at isolation and identification of acetic acid bacteria with characterization, optimization, and evaluation of their acetic acid productivity. materials and methods: samples from various fruits were screened for presence of acetic acid bacteria on glucose, yeast extract, ...