Kinesin1 is a motor protein that uses the energy from ATP hydrolysis to move intracellular cargoes along microtubules. It contains 2 identical motor domains, or heads, that coordinate their mechano-chemical cycles to move processively along microtubules. The molecular mechanism of coordination between head domains remains unclear, partly because of the lack of structural information on critical...

Fluid shear stress is the mechanical force generated by the blood flow which is applied over the apical surface of endothelial cells in situ. The findings of a recent study suggest that stress fibers and its associated focal adhesions play roles in mechano-signal transduction mechanism. Stress fibers are present along the apical and the basal portion of the endothelial cells. Endothelial cells ...

π-Conjugated compounds that exhibit tunable luminescence in the solid state under external mechanical stimuli have potential applications in sensors and imaging devices. However, no rational designs have been proposed that impart these mechano-responsive luminescent properties to π-conjugated compounds. Here we demonstrate a strategy for mechano-responsive luminescent materials by imparting amp...

• Mechano-optics such as tribo/high-pressure luminescence is useful in stress sensing. First to explore the possibility of lanthanide complexes sensors. A new family halogen Eu III diketonate with unique optics examined. Shows influence crystal packing/high-pressure compression on triboluminescence. Diamond anvil cell show material induces phase transition/peak shifting. Triboluminescence and h...

Introduction: Neuropathic pain syndromes are changes resulting from damage to neuronal pathways that are characterized by spontaneous burning sensation with accompanying allodynia and hyperalgesia. Since the treatments of neuropathic pain are poorly understood and existing treatments are often ineffective, it is important to increase our understanding of the neuropathic pain states in order ...

A magneto-mechano-electric generator based on a magnetostrictive metallic substrate and piezoelectric polymer is reported by Kyung Tae Kim, Kwi-Il Park, co-workers in article number 2000969. This harvests electric output signals under applied alternating-current magnetic fields, which are abundant daily life.