surface. MCR is unique in that it apparently inhibits DNA synthesis while binding to the plasma membrane (12, 13). This mechanism of action requires that the binding of MCR to the cell surface freezes on modifies the moleof the mom bnane in mediating cellular metabolism. Kunimotoetal. (13) hypothesize that the interaction between MCR and tumor cells is analogous to the interactions between bact...

The Multilingual Central Repository (MCR) is based on the design of the EuroWordNet database. The MCR holds WordNets in various languages (English, Spanish, Italian, Catalan and Basque), which are interconnected via an Inter-LingualIndex (ILI). In addition, the MCR holds a number of ontologies and domain labels related to all concepts. This paper describes the integration and evaluation of the ...

Colistin resistance was detected in 53 of 10,011 Escherichia coli (0.5%) by prospective phenotypic testing of consecutive clinical isolates in a single hospital in Barcelona, Spain (2012-15). The mcr-1 gene was retrospectively identified by PCR and sequencing in 15 of 50 available isolates. Each isolate had a unique PFGE pattern except for two. This clonal diversity supports the hypothesis of h...

We describe three cases of bloodstream infection caused by colistin-resistant Escherichia coli in patients in a tertiary hospital in Italy, between August 2016 and January 2017. Whole genome sequencing detected the mcr-1 gene in three isolated strains belonging to different sequence types (STs). This occurrence of three cases with mcr-1-positive E. coli belonging to different STs in six months ...

Methyl-coenzyme M reductase (MCR) catalyzes the terminal step in the formation of biological methane from methyl-coenzyme M (Me-SCoM) and coenzyme B (CoBSH). The active site in MCR contains a Ni-F(430) cofactor, which can exist in different oxidation states. The catalytic mechanism of methane formation has remained elusive despite intense spectroscopic and theoretical investigations. On the bas...

The mcr-1 gene mediating mobile colistin resistance in Escherichia coli was first reported China 2016 followed by reports among different species worldwide, especially E. and Klebsiella . However, data on its transmission Salmonella are still lacking. This study analyzed the antimicrobial (AMR) profiles presence 755 foodborne from 26 provinces of mainland, 2016. Genomic features two mcr-1- carr...

Seven wastewater treatment plants (WWTPs) with different population equivalents and catchment areas were screened for the prevalence of the colistin resistance gene mcr-1 mediating resistance against last resort antibiotic polymyxin E. The abundance of the plasmid-associated mcr-1 gene in total microbial populations during water treatment processes was quantitatively analyzed by qPCR analyses. ...

Metabolic clearance (MCR) and production rates (PR) of human thyrotropin (hTSH) were determined by the constant infusion to equilibrium method 57 times in 55 patients. 16 control patients had a mean hTSH MCR of 50.7 ml/min. The mean hTSH MCR was significantly (P < 0.02) higher in 19 euthyroid men (51.6 ml/min) than in 12 euthyroid women (43.0 ml/min), but this apparent sex difference disappeare...

On 18 November 2015, Liu et al. reported the first description of plasmid-mediated colistin resistance (mcr-1 gene) in food animals, food and humans in China [1]. In this issue, Kluytmans-van den Bergh et al. report on their finding of the mcr-1 gene in Escherichia coli isolates from three (1.5%) of 196 samples of chicken meat collected at Dutch supermarkets, one in 2009 and two in 2014 [2]. Th...