Background Due to increasing colistin usage, the dissemination of the colistin-resistant gene mcr-1 has been increasingly investigated. The aim of this study was to determine whether a traveler on a short-term international trip to a developing country could bring mcr-1 back to their home country. Materials and methods Thirty-four travel events from Japan to Vietnam encompassing 19 travelers ...

The mcr-1 gene was found in 11 isolates from a Portuguese Salmonella collection (n = 1,010; 58 serotypes; 2002-15) of clinical samples, foodstuff, food-animals and water. Mcr-1 has been located on different plasmids (IncX4/IncHI2) in pig-associated multidrug-resistant, copper-tolerant S.1,4,[5],12:i:-/ST34 and S. Rissen/ST469 clones from human and pork products since at least 2011. Our data hig...

Medical case retrieval (MCR) is information retrieval in a collection of medical case descriptions, where descriptions of patients’ symptoms are used as queries. We apply known text retrieval techniques based on query and document expansion to this problem, and combine them with new algorithms to match queries and documents with Medical Subject Headings (MeSH). We ran comprehensive experiments ...

Dear Editor, Following the recent description of transmissible plasmid-mediated colistin resistance encoded by mcr-1 in clinical and veterinary Escherichia coli and Klebsiella pneumoniae isolates in China,1 several groups have reported mcr-1 in colistin-resistant isolates from humans and food animals across Asia2–4 to Europe.5–8 It is evident that mcr-1 has disseminated globally. We performed a...

The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. ...

To the editor: In a recent editorial [1], Kluytmans reports on the rise of plasmid-mediated colistin resistance that has occurred worldwide since its first description in 2016 [2]. Antimicrobial resistance, especially in Gram-negative bacteria, has been recognised as a serious threat to human health, and colistin, as well as tigecycline, is often the only therapeutic option for infections cause...

Resumen: Este art culo presenta el dise~ no inicial del "Multilingual Central Reposi-tory". La primera versii on del Mcr integra, siguiendo en el marco de EuroWordNet, cinco wordnets locales (incluyendo tres versiones del WordNet de Princeton), la Top Ontology the EuroWordNet, los dominios de MultiWordNet y cientos de miles de nuevas relaciones semm anticas y propiedades adquiridas automm atica...

A majority of t(14;18) translocations have been shown to cluster at one of two sites on chromosome 1 8, called the major breakpoint region (mbr) or the minor cluster region, (mcr), which map within or flanking the bcl-2 protooncogene. respectively. We have determined the nucleotide sequence for a portion of the mcr, and constructed oligonucleotides that were used to perform the polymerase chain...

ABTRACT The use of recombinant genetic technologies for population manipulation has mostly remained an abstract idea due to the lack of a suitable means to drive novel gene constructs to high frequency in populations. Recently Gantz and Bier showed that the use of CRISPR/Cas9 technology could provide an artificial drive mechanism, the so-called Mutagenic Chain Reaction (MCR), which could lead t...

A Klebsiella pneumoniae clinical strain, named SCKP83, was isolated and found to be resistant to colistin thanks to the presence plasmid-borne colistin resistant gene mcr-1. The strain was subjected to whole genome sequencing and conjugation experiments. The subsequent analysis indicated that the strain belongs to ST15 and the capsular type K41. In SCKP83, mcr-1 was carried by a 97.4-kb non-sel...