نتایج جستجو برای: mbl2

تعداد نتایج: 273  

2013
Dominique S. Michaud Afshan Siddiq David G. Cox Danielle M. Backes Federico C. F. Calboli Michael E. Sughrue J. Michael Gaziano Jing Ma Meir Stampfer Shelley S. Tworoger David J. Hunter Carlos A. Camargo Andrew T. Parsa

BACKGROUND AND AIMS The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers. METHODS To examine the role of the lectin complement pathway, we combined data from prospectively collected cohorts with available DNA specim...

2012
D. Shane O'Mahony Bradford J. Glavan Tarah D. Holden Christie Fong R. Anthony Black Gail Rona Paula Tejera David C. Christiani Mark M. Wurfel

INTRODUCTION Common variants in genes related to inflammation, innate immunity, epithelial cell function, and angiogenesis have been reported to be associated with risks for Acute Lung Injury (ALI) and related outcomes. We tested whether previously-reported associations can be validated in an independent cohort at risk for ALI. METHODS We identified 37 genetic variants in 27 genes previously ...

2014
Celia N. Sanchez-Dominguez Miguel A. Reyes-Lopez Adriana Bustamante Ricardo M. Cerda-Flores Maria del C. Villalobos-Torres Hugo L. Gallardo-Blanco Augusto Rojas-Martinez Herminia G. Martinez-Rodriguez Hugo A. Barrera-Saldaña Rocio Ortiz-Lopez

UNLABELLED Environmental and genetic factors may modify or contribute to the phenotypic differences observed in multigenic and monogenic diseases, such as cystic fibrosis (CF). An analysis of modifier genes can be helpful for estimating patient prognosis and directing preventive care. The aim of this study is to determine the association between seven genetic variants of four modifier genes and...

2017
Mi Ae Kim Moon Kyung Yoon Seung Hyun Kim Hae Sim Park

Baker's asthma is the most prevalent occupational asthma, and IgE-mediated response is known as a major pathogenesis. However, recent studies have suggested the involvement of innate immune response because wheat flour contains bacterial endotoxins or lipopolysaccharides. To further understand a role of innate immune response in the development of work-related respiratory symptoms (WRS) in bake...

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