Analysis of accumulation of repair and checkpoint proteins at repair sites in yeast nuclei has conventionally used chemical agents, ionizing radiation or induction of endonucleases to inflict localized damage. In addition to these methods, similar studies in mammalian cells have used laser irradiation, which has the advantage that damage is inflicted at a specific nuclear region and at a precis...

To reveal the mechanism of the easy discretization and low damage in kernel dispersal, this paper analyzes the microscopic analysis of beak structures and finds that maxillary outside cells of the beak are dense and hard. Besides, the cuticle wrapping on maxilla of chicken's beak can reduce corn kernels damage in the discrete process of ear. From force test of corn ear, we find that value of x ...

Objective: To evaluate low-molecular-weight (LMW) DNA as possible prognostic biomarker in acute ischemic and hemorrhagic stroke. Methods:  LMW DNA samples were isolated from plasma and cerebrospinal fluid by phenol deproteinization, analyzed by gradient polyacrylamide electrophoresis and quantified by spectrophotometry. Results: Two common types of the stroke, ischemic and hemorrhagic, differ...

HIGHLIGHTS Malnutrition damages the biomechanical and densitometric properties of femur. Aerobic exercise reduces maximum femoral load until fracture in malnutrition. increases damage to BMC BMD established by

DNA damage is considered of paramount importance in aging. Among causes of this damage, free radical attack, particularly from mitochondrial origin, is receiving special attention. If oxidative damage to DNA is involved in aging, long-lived animals (which age slowly) should show lower levels of markers of this kind of damage than short-lived ones. However, this possibility has not heretofore be...

In this paper, a maximum entropy-based general framework for probabilistic fatigue damage prognosis is investigated. The proposed methodology is based on an underlying physics-based crack growth model. Various uncertainties from measurements, modeling, and parameter estimations are considered to describe the stochastic process of fatigue damage accumulation. A probabilistic prognosis updating p...

OBJECTIVE The Cutaneous Assessment Tool (CAT) is a comprehensive, semiquantitative tool for the assessment of skin disease in juvenile dermatomyositis (DM). The goal of this study was to determine whether alternative scoring methods would shorten the CAT without compromising its measurement characteristics. METHODS A total of 113 children with juvenile DM were assessed at baseline; 94 were as...