Super enhancers have been shown to present a role in tumorigenesis, indicating that they could be promising therapeutic targets for cancer treatment. Long noncoding RNAs (lncRNAs) emerged as important regulators of progression. Here, the lncRNA LINC00094 cutaneous squamous carcinoma (cSCC) was examined. Elevated expression detected cSCC cell lines, compared with normal human epidermal keratinoc...

C ardiovascular risk reduction therapy in diabetic patients reduces vascular events (1) by retarding atherosclerosis and improving vascular reactivity. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are integral to the vascular changes of atheroma, and MMP-9 and TIMP-1 are raised in diabetes (2). We hypothesized that global risk reduction of intensified diabetes and cardiovascula...

Pathogenesis of Fibrosis with Chronic Hepatitis C: Hepatic fibrosis is a dynamic scarring process in which chronic inflammation stimulates production and accumulation of collagen and extracellular matrix proteins. The hepatic stellate cells are the primary cells responsible for producing these extracellular matrix proteins. Over time, with chronic hepatitis C infection, the total collagen conte...

Pathogenesis of Fibrosis with Chronic Hepatitis C: Hepatic fibrosis is a dynamic scarring process in which chronic inflammation stimulates production and accumulation of collagen and extracellular matrix proteins. The hepatic stellate cells are the primary cells responsible for producing these extracellular matrix proteins. Over time, with chronic hepatitis C infection, the total collagen conte...

Pathogenesis of Fibrosis with Chronic Hepatitis C: Hepatic fibrosis is a dynamic scarring process in which chronic inflammation stimulates production and accumulation of collagen and extracellular matrix proteins. The hepatic stellate cells are the primary cells responsible for producing these extracellular matrix proteins. Over time, with chronic hepatitis C infection, the total collagen conte...

Background: Osteoarthritis (OA) is a progressive, age-associated disease that is characterized with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane. Considering the complications of common treatments of OA, including non-steroidal anti-inflammatory drug (NSAIDs) and corticosteroids, investigating new treatments for this disorder is crucial. Recently,...

BACKGROUND AND PURPOSE Elevated levels of matrix metalloproteinases (MMPs), particularly MMP-1 and MMP-9, have been implicated in plaque rupture. It has been suggested that inhibition of MMPs may stabilize vulnerable atherosclerotic plaques and improve clinical outcome. The aim of the study was to investigate the ability of doxycycline, a nonspecific MMP inhibitor, to reduce MMP concentration i...

Aim. To evaluate the severity of coronary atherosclerosis and its association with biochemical markers fibrosis in patients artery disease (CAD) resistant hypertension (RHT). Material methods . The study included 39 CAD RHT. All underwent 24-hour blood pressure (BP) monitoring, office BP numbers were measured. Laboratory diagnostics routine tests, as well determination serum lipocalin, plasma c...

In situ hydrogelation of injectable precursors upon biological stimulus is relevant to generate hydrogels under mild conditions and, potentially, at a side interest. Here, it shown that hydrolytic enzymes can be used initiate the formation covalent hydrogel networks, realizing cleavage-leading-to-gelation strategy. For this purpose, two-component system used, consisting 4-arm polyethylene glyco...

Context: Endometrial breakdown during menstruation and dysfunctional bleeding is triggered by the abrupt expression of matrix metalloproteinases (MMPs), including interstitial collagenase (MMP-1). The paracrine induction of MMP-1 in stromal cells via epithelium-derived IL-1 is repressed by ovarian steroids. However, the control by estradiol (E) and progesterone (P) of endometrial IL-1 expressio...