background: current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. this study was undertaken to investigate the combination effects of il-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(mmp-1) in il-lα-treated bovine nasal cartilage (bnc) explants. methods: bnc explants were cultu...

objective(s):n-myc downstream regulated gene 2 (ndrg2) is a candidate gene for tumor suppression. the expression of ndrg2 is down-regulated in several tumors including lung cancer. the aim of this study was to explore the effect of ndrg2 overexpression on invasion, migration, and enzymatic activity of matrix metalloproteinase-2 (mmp-2) and -9 (mmp-9) in human lung adenocarcinoma a549 cells.  ma...

background: the role of matrix metalloproteinase 9 (mmp9) in tumor invasion and progression is prominent. a single nucleotide polymorphism (snp) in the promoter region of mmp9 (-1562 c/t) increases the transcription and expression of this gene. on the other hand, mhc class i chain-related protein a and b (mica/b) in soluble forms may impair tumor immunogenicity by reducing natural killer group ...

BACKGROUND The gastric epithelium is continuously exposed to toxic reactive oxygen species and matrix metalloproteinases (MMPs) are the enzymes known for their roles in the invasion of tumor cells. Here, we report the suppression of matrix metalloproteinase 3 (MMP-3) in gastric cancer cell line AGS by small interfering RNA (siRNA) transfection and its potential role in gastric cancers. METHOD...

OBJECTIVE To assess the likely importance of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the arthritic process. METHODS Synovial samples from seven joints with rheumatoid arthritis and three osteoarthritic joints were analysed by indirect immunofluorescence microscopy. Using specific human antisera, we documented the frequencies and distributions of collagenase, stromelys...