Pregnancy poses a unique challenge to patients with sickle cell disease and β-thalassemia, who often have exacerbations of hemolysis or anemia during the gestational period, experience higher rates of obstetric and fetal complications, and may have distinct underlying comorbidities related to vasculopathy and iron overload that can endanger maternal health. Optimal management of pregnant women ...

BACKGROUND There is no consensus on the most effective and best tolerated first-line antiarrhythmic treatment for fetal tachyarrhythmia. The purpose of this systematic review and meta-analysis was to compare the efficacy, safety, and fetal-maternal tolerance of first-line monotherapies for fetal supraventricular tachycardia and atrial flutter. METHODS AND RESULTS A comprehensive search of sev...

BACKGROUND The measurement of maternal serum human chorionic gonadotropin as a predictor of fetuses with Down syndrome has been in use since 1987. OBJECTIVES To determine the correlation between extremely high levels of hCG at mid-gestation and maternal and fetal complications. METHODS The study group consisted of 75 pregnant women with isolated high levels of hCG (> 4 MOM) at mid-gestation...

Pregnancy in the women aged less than 20 years is an important public health issue, especially in developing countries. In Iran, limited studies have focused on the effects of maternal age on gestational and neonatal outcomes to demonstrate the pregnancy outcomes in young women. The present study aimed to investigate the maternal and neonatal complications in the pregnant women aged less than 2...

INTRODUCTION Sjögren's syndrome is a rare systemic autoimmune disorder associated with pregnancy (0.3-0.6%). The typical occurrence of anti-Ro/SSA and anti-La/SSB autoantibodies in the maternal serum can modify the perinatal outcome: neonatal lupus and congenital heart block are the most common fetal complications. CASE we report a case of pregnancy complicated by a secondary form of SS assoc...

Obesity, the most common metabolic disorder, concerns, among others, women of reproductive age and, when it occurs before or during pregnancy, constitutes a major risk factor for both maternal and fetal complications. The complications of obesity in a prospective mother include subfertility, miscarriage, thrombo-embolism, hypertensive disorders, metabolic syndrome, preterm delivery and higher f...

Relapsing-fever borreliosis caused by Borrelia duttonii is a common cause of complications of pregnancy, miscarriage, and neonatal death in sub-Saharan Africa. We established a murine model of gestational relapsing fever infection for the study of the pathological development of these complications. We demonstrate that B. duttonii infection during pregnancy results in intrauterine growth retard...

Introduction: Hypertensive disorder of pregnancy complicates around 5-10% all pregnancies. Hyperuricemia is one the common findings in pre-eclampsia. The uric acid level pre-eclamptic women increased before onset hypertension and proteinuria. increase serum associated with an risk adverse fetal outcomes like IUGR, prematurity, IUFD severity maternal hypertensive disorders pre-eclampsia, severe ...

conclusions the pregnancy adaptation training package increased the adaptation and maternal-fetal attachment scores in pregnant women with a history of baby loss. results before the intervention, there were no statistically significant differences between the study and control groups in terms of maternal-fetal attachment (p = 0.280) and adaptation to pregnancy (p = 0.883). however, following th...

INTRODUCTION Sacrococcygeal teratoma (SCT) is a rare tumor in the general population, arising from multipotent stem cells. Whereas most of the cases diagnosed postnatally have good prognosis, the rate of mortality and morbidities associated with prenatally diagnosed SCT remain high, with a reported mortality rate of 30% to 50%. The outcome of fetal SCT can be unpredictable, with some cases with...