The article by Revesz and Khan is an excellent summary of the state of our knowledge of margin width in relation to breast cancer recurrence. The importance of preventing local recurrence in women who undergo breast-conserving therapy (BCT) for early-stage breast cancer is underscored by the fact that local recurrence is associated with increased cost, psychosocial distress for the patient, and...

Major conclusions and recommendations of the National Commission on Air Quality on issues of health in the Clean Air Act are presented. The issues revolve mainly about the standard setting processes for ubiquitous pollutants, controlled through ambient air quality standards (Section 109), and for hazardous pollutants controlled through emission standards (Section 112). The conceptual difficulti...

A brief history of the development of milk pasteurisation is presented and updated. Concerns about the margin of safety provided by current pasteurisation standards in terms of milk-borne pathogens such as mycobacteria (in particular Mycobacterium paratuberculosis) and other emerging pathogens such as Listeria monocytogenes and Escherichia coli O157:H7 are discussed. With the exception of the e...

DISCUSSION: Health and Safety Code section 39606 (d) (1) requires the Board, in consultation with the Office of Environmental Health Hazard Assessment, to review all current health-based California ambient air quality standards to determine whether, based on public health, scientific literature, and exposure pattern data, the standards adequately protect the health of the public, including infa...

Although revenue management (RM) originates from service industries, its ideas are also relevant for manufacturing environment. In this paper, we consider RM approaches for demand fulfillment in a make-to-stock (MTS) production system with known exogenous replenishments and stochastic demand from multiple customer classes. We propose a safety margin model which borrows the “safety stock” idea f...

INTRODUCTION Occupational exposure limits (OELs) for the protection of workers have been around at least since 1939 when the National (later changed to American) Conference of Governmental Industrial Hygienists (ACGIH) published its inaugural acceptable workplace exposure limits (now known as threshold limit values, or TLVs). In 1970, the U. S. Occupational Safety and Health Act incorporated by...