Emerging nanotechnologies have, and will continue to have, a major impact on the pharmaceutical industry. Their influence on a drug's life cycle, inception to delivery, is rapidly expanding. As the industry moves more aggressively toward continuous manufacturing modes, utilizing Process Analytical Technology (PAT) and Process Intensification (PI) concepts, the critical role of transport phenome...

This contribution presents a novel approach to address the scheduling of resource-constrained flexible manufacturing systems (FMSs). It deals with several critical features that are present in many FMS environments in an integrated way. The proposal consists in a constraint programming (CP) formulation that simultaneously takes into account the following sub-problems: (i) machine loading, (ii) ...

We aimed to study the composition and availability of various vitamin preparations in the Indian market, data about which was collected from an annual Drug Compendium. The preparations were assessed for total number, different formulations, constituents and amount of each constituent present in the formulation. A large number of vitamin supplements are available in the Indian market. It include...

A supervisory controller for Discrete Event (DE) Systems is presented that uses a novel Matrix Formulation. This matrix formulation makes it direct to write down the DE controller from standard manufacturing tools such as the Bill of Materials or the assembly tree. The matrices also make it straightforward to actually implement the DE controller on a manufacturing workcell for sequencing the jo...

Introduction In the era of process modeling of composite materials, 3D simulation of manufacturing processes is desirable considering the manufacturing trend where parts became more complex leading to complex 3D stress-strain states. Moreover, coupling of sub-processes that are happening simultaneously such as macro-scale preform processes, flow advancement and solid and fluid interaction requi...

The world market for CO2/CH4 separation using membrane technology is getting bigger and polysulfone (PSf) is one of the most widely investigated polymer membrane materials. However, the existing PSf membranes performances are insufficient to fully exploit these opportunities. Therefore, modification that would produce membrane that fit the needs of target separation performances is a main issue...

INTRODUCTION Kamsaharitaki Avaleha is a well-known ayurvedic preparation. Considering certain inconveniences of Avaleha, an attempt has been made to convert it into granules that are convenient in handling, dispensing, and storage. AIM To convert Kamsaharitaki Avaleha into granules form and develop standard manufacturing procedure. MATERIALS AND METHODS Seven pilot batches were prepared to ...

Pharmaceutical and biomedical industries demand simple, safe and reproducible processing methods thus urging the development of novel straightforward manufacturing approaches. The product manufacturing by the green processing of admixtures and end-product would avoid long and costly purification (downstream) steps. In this work, the supercritical fluid technology is used for the green processin...

"Primum non nocere' must be the first quality of veterinary immunological medicinal products. Throughout the manufacturing process, stage by stage, various ingredients and/or operations could be responsible for safety problems observed when the product is administered. During the preliminary stages, various ingredients--e.g. master seed strains (virus, bacteria or parasite), cell substrates (ce...

We consider manufacturing problems which can be modelled as finite horizon Markov decision processes for which the effective reward function is either a strictly concave or strictly convex functional of the distribution of the final state. Reward structures such as these often arise when penalty factors are incorporated into the usual expected reward objective function. For convex problems ther...