نتایج جستجو برای: mannich reaction

تعداد نتایج: 412927  

2010
Wen-Jun Lei Shu-Zhong Zhan Seik Weng Ng

The title compound, C(16)H(25)NO(2), which was synthesized by a Mannich reaction route, is a rare example of an organic compound containing the six-membered oxazine ring. The ring adopts a chair conformation and the N atom is pyramidal. The N atom serves as a hydrogen-bond acceptor to the phenolic OH group.

Journal: :Tetrahedron 2021

Abstract A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry. The reaction between β-aryl/heteroaryl substituted nitroalkanes glyoxylate imine provides β-nitro-amines with good selectivity (70:30 >95:5) syn, anti-diastereoisomers. Reductive cyclisation BF3.OEt2...

1998
Zhi-Hua Jiang Dimitris S. Argyropoulos

The reactivity of lignin model compounds under Mannich conditions with piperidine and formaldehyde was studied. The piperidinomethyl group was confirmed to be introduced quantitatively at sterically unhindered positions ortho to a phenolic hydroxyl when the substrate was allowed to react under ambient conditions. The sequential application of the Mannich reaction followed by quantitative P NMR ...

2013
Misbah ur Rehman Muhammad Imran Muhammad Arif Muhammad Farooq

Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity m...

2012
Gert Callebaut Sven Mangelinckx Pieter Van der Veken Karl W Törnroos Koen Augustyns Norbert De Kimpe

The asymmetric synthesis of new chiral γ-chloro-α,β-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene)glycinamides across chiral α-chloro-N-p-toluenesulfinylaldimines was developed. The resulting (S(S),2S,3S)-γ-chloro-α,β-diaminocarboxylamides were formed with the opposite enantiotopic face selectivity as compared to the (S(S),2R,3R)-γ-...

2014
Ebtehal S. Al-Abdullah Hanaa M. Al-Tuwaijri Hanan M. Hassan Mogedda E. Haiba Elsayed E. Habib Ali A. El-Emam

The reaction of 5-(1-adamantyl)-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the corresponding N-Mannich bases. The newly synthesized N-Mannich bases were tested for in vitro inhibitory activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Six compounds ...

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