Introduction Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disease, characterized by the transplacental passage of maternal antibodies (anti-SSA/Ro and/or anti-SSB/La) into the fetal circulation system, inducing clinical manifestation in the neonate. The most serious clinical manifestation of NLE is a nonreversible complete congenital heart block (CHB), and other common manif...