The purpose of this study was to investigate the cytotoxic profiles of different ternary natural deep eutectic solvents (NADESs) containing water. For this purpose, five different NADESs were prepared using choline chloride as a salt, alongside five hydrogen bond donors (HBD) namely glucose, fructose, sucrose, glycerol, and malonic acid. Water was added as a tertiary component during the eutect...

BACKGROUND Combined Malonic and Methylmalonic Aciduria (CMAMMA) is a rare recessive inborn error of metabolism characterised by elevations of urine malonic acid (MA) and methylmalonic acid (MMA). Nearly all reported cases are caused by malonyl-CoA decarboxylase (MCD) deficiency. Most patients have metabolic acidosis, developmental delay, seizures and cardiomyopathy. CMAMMA was also described in...

Concurrieron a la ceremonia diversas personalidades en representación de la Academia Nacional de Ciencias, la Academia Nacional de Medicina, la Academia Peruana de Salud, la Academia Peruana de Cirugía, la Universidad Nacional Mayor de San Marcos y la Universidad Peruana Cayetano Heredia; así también, editores de revistas médico–científicas, miembros del Consejo Consultivo de la Revista, person...

Lifelong employment commitments are a relatively uncommon employment contract. We …nd that three factors can explain their existence in academia – (i) non-contractibility of output, (ii) discipline-speci…c investment by a faculty member that enhances the chance of high output within the profession but that also signi…cantly diminishes the faculty member’s outside-occupation alternatives and (ii...

One of the goals of the recent workshop, “An Eye on Glaucoma: New Opportunities for Treatment,” was to highlight areas of glaucoma research that, with appropriate funding, are ripe for major advancement for prevention, diagnosis, and treatment. Another goal was the exploration of collaborative partnership and the process for facilitating translation of these areas, not just for glaucoma but for...

Academia-industry relationship is not like that of technology donator-acceptor, but is of interactive and collaborative nature, acknowledging and ensuring mutual respect for each other’s role and contributions with an eye to attaining the true purpose of such relationships, namely, bringing about research-outcome synergy. Indeed, academia-industry interactions are a system that requires active ...

The first total synthesis of (+/-)-actinophyllic acid (1) is reported. Key steps of this synthesis include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-Cope-Mannich rearrangement that assembled the core structure of the natural product's unique ring system. The synthesis was accomplished from di-tert-butyl malonate in 8% overall yield by a concise sequenc...

The trisubstituted enolate- and C-C bond-forming capacities of engineered carboxymethylproline synthases CMPSs are coupled with the malonyl-CoA synthetase MatB to enable stereoselective preparation of 5- and 6-membered N-heterocycles functionalised with alkyl-substituted carboxymethyl side chains, starting from achiral alkyl-substituted malonic acids and L-amino acid semialdehydes. The results ...

The effect of spatially correlated noise on Turing structures is analyzed both experimentally and numerically. Using the photosensitive character of the chlorine dioxide-iodine-malonic acid reaction-diffusion system, spatial randomness is introduced in the system. In the presence of noise, Turing patterns appear and are stable at levels of average illumination that would be more than sufficient...