Cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment and play an important role in disease progression treatment outcome. Here we used single-cell transcriptomics, CNV analysis, situ stainings to elucidate yet unresolved intra-tumoral CAF heterogeneity melanoma, basal squamous cell carcinoma. We identified three major subtypes, with their presence being indicat...

ALL: acute lymphoblastic leukemia BPDCN: blastic plasmacytoid dendritic cell neoplasm CVAD: cyclophosphamide, vincristine, doxorubicin, dexamethasone CVAD A1B: cyclophosphamide, vincristine, doxorubicin, dexamethasone alternating with methotrexate and cytarabine HSCT: hematopoietic stem cell transplantation LRT: localized radiotherapy LS-BPDCN: localized skin-limited blastic plasmacytoid dendri...

Phyllodes tumors are rare fibroepithelial neoplasms of the breast. In the literature, borderline or malignant tumors have been reported to present with unusual characteristics including a short clinical history and extremely rapid tumor growth. Skin necrosis and infection sometimes accompanies these malignancies. Giant phyllodes tumors have a good prognosis when treated with total mastectomy, b...

background: thromboembolism is the most important complication of cancers.the aim of this study was to determine d-dimer levels in benign and malignant tumors of the uterus, ovary and cervix. subjects and methods: this was a cross sectional study and it was conducted on 90 female patients referred to imam khomeini and arash hospitals because of uterine, cervical and ovarian tumors in 2013-2014....

background and aims. mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. the distribution and significance of mast cells in many tumors have been demonstrated. however, few studies have evaluated mast cell infiltration in salivary gland tumors. in this study, mast cell counts were evaluated in benign and malignant salivary gland tumors. mat...

The cutaneous human papillomavirus (HPV) 8 is clearly involved in skin cancer development in epidermodysplasia verruciformis patients and its early genes E2, E6, and E7 have been implicated in cell transformation in vitro. To examine the functions of these genes in vivo we integrated the complete early region of HPV8 into the genome of DBA/Bl6 mice. To target their expression to the basal layer...

Introduction: Most common glioma tumors are tumors of the central nervous system (CNS) which are the cause of about 40 to 50 percent of brain tumors. This type of cancer includes 2 to 3 percent of cancers in the world. Conventional MRI is powerless in the detection and differentiation of benign and malignant tumors. In this case, diffusion weighted imaging (DWI) can create cont...

  Background: Tumors involving the hand skeleton are rare. However, a basic knowledge of hand tumors is necessary for every clinician. This is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. Methods: This study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, Imam Khomeini Hospital in Te...

background: phyllodes tumors are uncommon neoplasms of the breast. data about their outcome is limited. this study aims to evaluate patients diagnosed with phyllodes tumors in terms of local recurrence, distant metastasis and overall survival. methods: we retrospectively reviewed the medical records of 129 women with phyllodes tumors who referred to our center from 1999 to 2013. clinical and pa...