Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a verte...

Fibrous dysplasia is a rare bone disease caused by an abnormal proliferation of fibrous tissue in bone. We retrospectively evaluated eight patients (female to male ratio 3:1, mean age 22.5 years, range 10-32) with a monostotic form who were treated between 1996 and 2006. Two each were affected in the lower jaw, the upper jaw, the midface, and the frontoparietal region. Most patients were referr...

Undifferentiated pleomorphic sarcoma, known as malignant fibrous histiocytoma, is a malignant neoplasm that arises in both soft tissue and bones. In 2002, the World Health Organization declassified malignant fibrous histocytoma as a formal diagnostic entity and renamed it 'undifferentiated pleomorphic sarcoma not otherwise specified.' It most commonly occurs in the lower extremities and rarely ...

Malignant fibrous histiocytoma of the kidney is an extremely rare tumor that is thought to arise from the renal capsule. Radical nephrectomy is the standard treatment for localized disease but 25% of patients die of metastatic disease despite radical surgical resection. In the absence of clear pathogenetic information, adjuvant treatment remains empiric. Herein, we describe the case of a previo...

A case of malignant solitary fibrous tumor of the thigh with liver and lung metastasis, suspicious of non-islet cell tumor-associated hypoglycemia is reported. The patient, a 76-year-old woman, was initially aware of an increasing soft tissue tumor in the left thigh, and episodes of hypoglycemia gradually developed. These frequent episodes ceased after resection of the thigh tumor, which was di...

1. de Perrot M, Fischer S, Bründler MA, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura. Ann Thorac Surg. 2002;74:285–93. 2. Marak CP, Dorokhova O, Guddati AK. Solitary fibrous tumor of the pleura. Med Oncol. 2013;30:573. 3. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol. ...

INTRODUCTION It has been reported that cardiac malignant fibrous histiocytomas occur more frequently in the left side of the heart, especially in the left atrium, but rarely invade the mitral valve. We present a case with a giant malignant fibrous histiocytoma with an unusual localization involving almost the entire left atrium, mitral valve, and left superior pulmonary vein. CASE PRESENTATIO...

BACKGROUND Malignant fibrous histiocytoma is a sarcoma of uncertain origin that can be found both in soft tissues and in bones. It is currently called undifferentiated pleomorphic sarcoma not otherwise specified and it represents a final common pathway in several tumors that are subject to the progress of dedifferentiation. Local recurrence of the tumor in the same location where it was origina...