Background: The usefulness of S100 as a prognostic marker and aid in follow-up care in patients with malignant melanoma as well as in individuals with various neurological pathologies is well known. The aim of this study was to investigate its release and clinical relevance in benign and malignant disorders beyond these indications to elucidate tumor and organ specificity of S100. Methods: S100...

BACKGROUND To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders. MATERIAL AND METHODS Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders (PMD)) and Group 3 (47 healthy controls). EBV DNA salivary analysis was performed by PCR. RESUL...

Tumour markers are widely used in clinical practice. Elevated tumour markers can be observed in both malignant and benign conditions. Therefore, it is important for clinicians to be aware of the association of tumour markers with various disorders so that unnecessary investigations can be avoided without missing the malignant disorders. A 58-year-old woman who presented with weight loss and ele...

The aim of the present study was to investigate the influence of some possible risk factors in development of ALL. A hundred and sixteen children diagnosed as ALL over a three year period in our institute were involved in the study. Their ages ranged between 1 and 14 years (7.35±3.8). Four hundred children without any malignant or chronic disorders served as the control group. Male sex, increas...

The shadow of carcinoma lies heavy over all breast disorders. Women are probably more conscious of the possibility of cancer of the breast than of any other organ so that, whether expressed or not, the thought that symptoms or signs in the breast may mean cancer is rarely far absent from their minds. To the doctor, too, the possibility of cancer of the breast is rightly a constant concern. But ...

BACKGROUND The purpose of this study was to determine inhibitor of apoptosis (IAP) expression, its relationship with p53, and epigenetic change in oral carcinogenesis that remain to be elucidated. METHODS We measured IAP and p53 expression in 44 oral potentially malignant disorders and their corresponding malignant-transformed oral squamous cell carcinomas (OSCCs), and in 44 other non-transfo...

Leukoplakia and erythroplakia are the two most common potentially malignant disorders of the oral cavity. The prognosis and overall survival of a patient with oral cancer is dependent on the early detection of any lesion that might identify a patient with higher risk than normal or with early infiltration before metastatic disease. The role of the general dentist cannot be overstressed and the ...