Malignant bone tumors in children occur rarely. Estimated annual incidence is 7 cases per 1.000.000 children under the age of 16. Due to its rare occurrence and often unspecific signs and symptoms, a lot of physicians do not consider this diagnosis early enough. Therefore it is not surprising that the majority of patients are referred to the pediatric oncologist when the disease is already in a...

Tumors of the foot and ankle are rare, and the particular clinicopathologic features, therapeutic approach, and outcomes in this setting are not well established. From January 2000 to December 2010, 72 patients with primary musculoskeletal tumors of the foot and ankle, both benign and malignant, were treated at a single institution. Of the 72 patients, 56% were female. The median age was 52 yea...

NELL-1 (NEL-like Protein 1) is an osteoinductive protein with increasing usage as a bone graft substitute in preclinical animal models. NELL-1 was first identified to have bone-forming properties by its overexpression in fusing cranial sutures. Since this time, addition of recombinant NELL-1 has been used to successfully induce bone formation in the calvarial, axial and appendicular skeleton. W...

Benign bone tumors of the foot and ankle typically present both a diagnostic and therapeutic challenge to podiatric surgeons. These lesions have a relatively low incidence of occuffence in the foot and ankle when compared to other regions of the body, and the behavior of these lesions may mimic malignant tumors. Not only is it impofiant to recognize a specific lesion to insure proper treatment,...

In this study characteristics and distribution of primary bone and soft tissue tumors which were operated in Inonu University Turgut Ozal Medical Center Department of Orthopaedics and Traumatology between January 2000 and December 2016 and comparison with the literature is aimed. Our study is retrospective and descriptive and 710 patients [275 M, 435 F, mean age: 30,67 (1-92)] who hospitalized ...

OBJECTIVE It has been reported that delayed scan of thallium-201 (201Tl) scintigraphy is useful for differentiating malignant tumors from benign lesions and for evaluating treatment response. However, physiological muscle uptake which usually increases in delayed scans, often makes it difficult to evaluate 201Tl uptake and its washout in bone and soft-tissue tumors. The purpose of this study wa...