We present novel architecture for True Random Number Generator based on Transition Effect Ring Oscillators. The TRNG consists of 16 transition effect oscillators and also malfunction detector. The malfunction detector can evaluate each TRNG bit right after it was generated. The evaluation utilizes described TRNG mathematical model. Our designed True Random Number Generator is implemented in Act...

CAPD catheter malfunction is a common problem. Obstruction due to wrapping by appendices epiploicae of sigmoid colon has been rarely reported in literature. We report a case of CAPD catheter malfunction caused by catheter tip migration and obstruction by appendices epiploicae that was successfully managed by laparoscopic hanging loop technique. This case report highlights the ease with which ep...

Neurodegenerative diseases often have multifactorial causes and are progressive diseases. Some are inherited while others are acquired, and both vary greatly in onset and severity. Impaired endoplasmic reticulum (ER) proteostasis, involving Ca2+ signaling, protein synthesis, processing, trafficking, and degradation, is now recognized as a key risk factor in the pathogenesis of neurological diso...

Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) activity is essential for long-term survival of postmitotic spinal motor neurons (SMNs) in vivo. Thus, mice that do not process miRNA in SMNs exhibit hallmarks of spinal muscular atrophy (SMA), including sclerosis of the spinal cor...

To the Editor:—A 77-yr-old man undergoing insertion of a J-splint for renal obstruction received general anesthesia delivered with an ADU anesthesia machine (Anesthesia Delivery Unit; Datex-Ohmeda, Stockholm, Sweden). A 5% desflurane vaporizer concentration setting with an O2/N2O mixture (2 and 3 l/min, respectively) resulted in stable inspired and expired desflurane concentrations (fig. 1). Im...

Complex II couples oxidoreduction of succinate and fumarate at one active site with that of quinol/quinone at a second distinct active site over 40 Å away. This process links the Krebs cycle to oxidative phosphorylation and ATP synthesis. The pathogenic mutation or inhibition of human complex II or its assembly factors is often associated with neurodegeneration or tumor formation in tissues der...

MOTIVATION Cancer encompasses various diseases associated with loss of cell cycle control, leading to uncontrolled cell proliferation and/or reduced apoptosis. Cancer is usually caused by malfunction(s) in the cellular signaling pathways. Malfunctions occur in different ways and at different locations in a pathway. Consequently, therapy design should first identify the location and type of malf...

Robotic surgery (RS) technology has undergone rapid growth in the surgical field since its approval. In clinical practice, failure of robotic procedures mainly results from a surgeon's inability or to a device malfunction. We reviewed the literature to estimate the impact of this second circumstance in RS and its consequent legal implications. According to data from the literature, device malfu...

An experimental ischemia (EI)-induced mouse model was used to analyze pathological and biochemical alterations in testes. Initial morphological changes were observed in Sertoli cells of EI testes at the light microscopic level. Examination of the ultrastructure using transmission electron microscopy confirmed that Sertoli cells were partially detached from the basement membrane of the seminifer...

EDITOR: We report the malfunction of an adjustable pressure limit (APL) valve on a KION (Siemens, SiemensElema AB, Solna, Stockholm, Sweden) anaesthesia workstation which occurred twice. The first time, the malfunction was detected during the pre-use manual check, but not by the automatic self-check. The second time, the malfunction occurred intermittently during ventilation of a patient but it...