OBJECTIVE To evaluate the efficacy of a parasite lactate dehydrogenase-based immunochromatographic antigen detection assay (optimal) against conventional light microscopy in the diagnosis of malaria at Military Hospital, Rawalpindi and Department of Pathology Army Medical College Rawalpindi from August to October 2002 in patients reporting sick with history suggestive of malaria. METHODS The ...

Artemisinin is a powerful drug that has been combined with other antimalarial drugs to combat malaria and it crucial recent achievements in reducing cases. However, the emergence of Plasmodium falciparum resistance against artemisinin become serious problem treatment. Our previous studies reported alkalinised digestive vacuole P. similarly concanamycin A. Concanamycin A specific inhibitor V-typ...

Birds harbouring several malarial parasites are common in the wild, and resolving such multiple infections is important for our understanding of host-parasite relationships. We propose a simple and reasonably accurate method for detecting and resolving multiple infections, based on the analysis of parasite cytochrome b DNA sequences: genetically mixed infections are first identified by double n...

The anemia in malarial infections is explained by the fact that each parasite destroys several red corpuscles. Reduction of hemoglobin out of proportion to the loss of red corpuscles is explained by the fact that there is always a partial loss of hemoglobin in certain of the surviving corpuscles due to parasitic action. Migration of parasites occurs in all aestivo-autumnal infections. If one wi...

Hemozoin, a bio-crystalline substance, is a hemin detoxification by-product of malaria parasites. The role of hemozoin crystals in host immune system modulation by malaria parasites, and how they interact with the immune system has been enigmatic. Here, we summarize recent progress in our understanding of how hemozoin might be interacting with the host immune system. In particular, the potentia...

over one thousand pages with copious illustrations, some in colours. It is on much the usual lines of such books, but is very complete and up-to-date. The sections relating to tropical diseases are rather more full than in most students' books. The plate illustrating malarial parasites shows unstained forms, which might well be replaced by one showing the parasites stained by one of the modific...