Although much is known about signaling factors downstream of Rho GTPases that contribute to epidermal differentiation, little is known about which upstream regulatory proteins (guanine nucleotide exchange factors [GEFs] or GTPase-activating proteins [GAPs]) are involved in coordinating Rho signaling in keratinocytes. Here we identify the GEF breakpoint cluster region (Bcr) as a major upstream r...

the closing ceremonies to mark the conclusion of our humanitarian efforts. Despite the oppressive, unrelenting heat, stifling body odor, the poverty surrounding us, and our longing to be reunited with family, the soldiers and airmen of Combined Joint Task Force Bravo were extremely proud of their accomplishments after months of being in El Salvador. This task force had been deployed to El Salva...

We examined the distribution of sialoglycoconjugates in the cerebellum of 9-week-old and 30-month-old rats using light microscopy and electron microscopy in combination with two lectins, Maackia amurensis lectin (MAL) for Sia(alpha)2-3Gal and Sambucus sieboldiana agglutinin (SSA) for Sia(alpha)2-6Gal. Each lectin showed characteristic staining patterns. In young adult rats, MAL stained a strong...

C1804: B. Ghezelayagh. On the adjustment od international stock prices to an exchange rate shock. Session CG243. Contributions in high frequency financial modelling. Room: MAL 541. Monday 18.12.2017 10:50 12:55. Abstract E0335: A. Daouia. Expectile depth. Session E033. New advances in statistical depth. Room: MAL 421. Sunday 17.12.2017 10:50 12:55. Abstract E0576: G. Rice. Inference for the aut...

The myelin and lymphocyte protein (MAL) is a tetraspan raft-associated proteolipid predominantly expressed by oligodendrocytes and Schwann cells. We show that genetic ablation of mal resulted in cytoplasmic inclusions within compact myelin, paranodal loops that are everted away from the axon, and disorganized transverse bands at the paranode--axon interface in the adult central nervous system. ...

Exosomes secreted by T cells play an important role in coordinating the immune response. HIV-1 Nef hijacks the route of exosome secretion of T cells to modulate the functioning of uninfected cells. Despite the importance of the process, the protein machinery involved in exosome biogenesis is yet to be identified. In this study, we show that MAL, a tetraspanning membrane protein expressed in hum...

The biological impact of novel nano-scaled drug delivery vehicles in highly topical therapies of bone diseases have to be investigated in vitro before starting in vivo trials. Highly desired features for these materials are a good cellular uptake, large transport capacity for drugs and a good bio-compatibility. Essentially the latter has to be addressed as first point on the agenda. We present ...

Median arcuate ligament (MAL) syndrome, also known as the celiac axis compression syndrome (CACS) is rare, and a topic of ongoing academic controversy. CACS is a diagnosis of exclusion, characterized by the clinical triad of postprandial abdominal pain, weight loss, and vomiting. The classic management of CACS involves the surgical division of the MAL fibers. We report successful treatment of a...

This paper uses Esperanto—a constructed language with transparent morphology but rich semantic-pragmatic components—to study antonymy and polarity. We investigate the distribution of the Esperanto antonymy morpheme ‘mal-’ (as in, for instance, ‘mal-alta’: antonym-tall, short) in a 4.3 million-word corpus, Tekstaro, and use it as an empirical basis to assess different theories of negative antony...

background: mal::::union:::: is the most common complication following distal radius fractures. aim of this study was to evaluate the results of distal radius corrective osteotomy and plate fixation by dorsal approach in the mal::::union::::. methods: in this retrospective study, 14 patients with neglected distal radius mal::::union:::: from 2005 to 2011 were studied. all patients were treated ...