We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. Groups of four subjects were enro...

3,3'-Diindolylmethane (DIM) is a stable condensation product of indole-3-carbanol, a potential breast cancer chemoprevention agent. Human breast cancer cell lines were studied to better understand its mechanisms. In vitro experiments were done in MCF-7, T47D, BT-20 and BT-474 cells using MTT, ELISA, immunoblotting assays, reverse transcription-PCR, protein half-life, confocal microscopy, cell f...

Progression of prostate cancer is believed to be dependent on angiogenesis induced by tumor cells. 3,3¶-Diindolylmethane (DIM) has been shown to repress neovascularization in a Matrigel plug assay and inhibit cell proliferation, migration, invasion, and capillary tube formation of cultured human umbilical vein endothelial cells. However, the molecular mechanism, by which DIM inhibits angiogenes...

Gastric antral vascular ectasia (GAVE) syndrome represents a rare cause of gastrointestinal bleeding. More extensive small-bowel involvement must be excluded in those patients with GAVE syndrome in whom aggressive endoscopic treatment of antral lesions results in lack of control of digestive bleeding, and for this subset of patients videocapsule endoscopy examination should be considered. Howev...

We have isolated a recessive mutation named diminuto (dim) from T-DNA transformed lines of Arabidopsis thaliana. Under normal growth conditions, the dim mutant has very short hypocotyls, petioles, stems, and roots because of the reduced size of cells along the longitudinal axes of these organs. In addition, dim results in the development of open cotyledons and primary leaves in dark-grown seedl...

Most bees forage for floral resources during the day, but temporal patterns of foraging activity vary extensively, and foraging in dim-light environments has evolved repeatedly. Facultative dim-light foraging behaviour is known in five of nine families of bees, while obligate behaviour is known in four families and evolved independently at least 19 times. The light intensity under which bees fo...

An Achromobacter xylosoxidans strain from the Tripoli central hospital produced a unique metallo-β-lactamase, designated TMB-1, which is related to DIM-1 (62%) and GIM-1 (51%). bla(TMB-1) was embedded in a class 1 integron and located on the chromosome. The TMB-1 β-lactamase has lower k(cat) values than both DIM-1 and GIM-1 with cephalosporins and carbapenems. The K(m) values were more similar ...

The rank+nullity theorem states that, if T is a linear transformation from a finite-dimensional vector space V to a finite-dimensional vector space W , then dim(V ) = rank(T ) + nullity(T ), where rank(T ) = dim(im(T )) and nullity(T ) = dim(ker(T )). The proof treated here is standard; see, for example, [14]: take a basis A of ker(T ) and extend it to a basis B of V , and then show that dim(im...

We consider embeddings of the complete t-ary trees of depth k (denotation T k,t) as subgraphs into the hypercube of minimum dimension n. This n, denoted by dim(T k,t), is known if max{k, t} ≤ 2. First we study the next open case max{k, t} = 3. We improve the known upper bound dim(T k,3) ≤ 2k + 1 up to limk→∞ dim(T k,3)/k ≤ 5/3 and derive the asymptotic limt→∞ dim(T 3,t)/t = 227/120. As a co-res...

We present a new regularization method, for d dim (Euclidean) quantum field theories in the continuum formalism, based on the domain wall configuration in (1+d) dim space-time. It is inspired by the recent progress in the chiral fermions on lattice. The wall ”height” is given by 1/M , where M is a regularization mass parameter and appears as a (1+d) dim Dirac fermion mass. The present approach ...